SMB01344
N-Methyl-4-pyridone-5-carboxamide
别名:
1,4-Dihydro-1-methyl-4-oxo-3-pyridinecarboxamide, 1,4-Dihydro-1-methyl-4-oxo-nicotinamide, 1-Methyl-1,4-dihydro-4-oxo-3-pyridinecarboxamide, 1-Methyl-4-pyridone-3-carboxamide, 1-Methyl-4-pyridone-5-carboxamide, 4-Py, 4PY, Me4PY, Met4PY, N1-Methyl-4-pyridone-3-carboxamide, N1-Methyl-4-pyridone-5-carboxamide
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关于此项目
经验公式（希尔记法）:
C7H8N2O2
化学文摘社编号:
分子量:
152.15
UNSPSC Code:
12352205
NACRES:
NA.77
MDL number:
SMILES string
[n]1(cc([c](cc1)=O)C(=O)N)C
InChI
1S/C7H8N2O2/c1-9-3-2-6(10)5(4-9)7(8)11/h2-4H,1H3,(H2,8,11)
InChI key
KTLRWTOPTKGYQY-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
solid
Quality Level
General description
N1-methyl-4-pyridone-5-carboxamide is involved in nicotinate and nicotinamide metabolism.
Application
Metabolomics research
Other Notes
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Aurélie Lenglet et al.
Toxins, 8(11) (2016-11-18)
N-methyl-2-pyridone-5-carboxamide (2PY, a major metabolite of nicotinamide, NAM) was recently identified as a uremic toxin. Recent interventional trials using NAM to treat high levels of phosphorus in end-stage renal disease have highlighted new potential uremic toxicities of 2PY. In the
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women.
Yoshino, et al.
Science (New York, N.Y.), 372, 1224-1229 (2021)
Renata Novak Kujundžić et al.
International journal of molecular sciences, 22(11) (2021-06-03)
The activity of nicotinamide N-methyltransferase (NNMT) is tightly linked to the maintenance of the nicotinamide adenine dinucleotide (NAD+) level. This enzyme catalyzes methylation of nicotinamide (NAM) into methyl nicotinamide (MNAM), which is either excreted or further metabolized to N1-methyl-2-pyridone-5-carboxamide (2-PY)
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