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SMB01344

N-Methyl-4-pyridone-5-carboxamide

Name: <I>N</I>-Methyl-4-pyridone-5-carboxamide
Brand: SIAL

别名:

1,4-Dihydro-1-methyl-4-oxo-3-pyridinecarboxamide, 1,4-Dihydro-1-methyl-4-oxo-nicotinamide, 1-Methyl-1,4-dihydro-4-oxo-3-pyridinecarboxamide, 1-Methyl-4-pyridone-3-carboxamide, 1-Methyl-4-pyridone-5-carboxamide, 4-Py, 4PY, Me₄PY, Met₄PY, N¹-Methyl-4-pyridone-3-carboxamide, N¹-Methyl-4-pyridone-5-carboxamide

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关于此项目

经验公式（希尔记法）:

C₇H₈N₂O₂

化学文摘社编号:

769-49-3

分子量:

152.15

UNSPSC Code:

12352205

NACRES:

NA.77

MDL number:

MFCD31726263

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属性

assay

≥95% (HPLC)

Quality Level

100

form

solid

SMILES string

[n]1(cc([c](cc1)=O)C(=O)N)C

InChI

1S/C7H8N2O2/c1-9-3-2-6(10)5(4-9)7(8)11/h2-4H,1H3,(H2,8,11)

InChI key

KTLRWTOPTKGYQY-UHFFFAOYSA-N

说明

General description

N¹-methyl-4-pyridone-5-carboxamide is involved in nicotinate and nicotinamide metabolism.

Application

Metabolomics research

Other Notes

For additional information on our range of Biochemicals, please complete this form.

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

MKCZ6207

MKCZ5479

MKCQ7019

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N-methyl-2-pyridone-5-carboxamide (2PY)-Major Metabolite of Nicotinamide: An Update on an Old Uremic Toxin.

Aurélie Lenglet et al.

Toxins, 8(11) (2016-11-18)

N-methyl-2-pyridone-5-carboxamide (2PY, a major metabolite of nicotinamide, NAM) was recently identified as a uremic toxin. Recent interventional trials using NAM to treat high levels of phosphorus in end-stage renal disease have highlighted new potential uremic toxicities of 2PY. In the

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women.

Yoshino, et al.

Science (New York, N.Y.), 372, 1224-1229 (2021)

Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer.

Renata Novak Kujundžić et al.

International journal of molecular sciences, 22(11) (2021-06-03)

The activity of nicotinamide N-methyltransferase (NNMT) is tightly linked to the maintenance of the nicotinamide adenine dinucleotide (NAD+) level. This enzyme catalyzes methylation of nicotinamide (NAM) into methyl nicotinamide (MNAM), which is either excreted or further metabolized to N1-methyl-2-pyridone-5-carboxamide (2-PY)

全球贸易项目编号

货号	GTIN
SMB01344-25MG	04065267377520
SMB01344-5MG	04065267377537