T0891
甲苯磺丁脲
analytical standard
别名:
1-丁基-3-（4-甲基苯磺酰基）脲, N-[(丁基氨基)羰基]-4-甲基苯磺酰胺
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关于此项目
经验公式（希尔记法）:
C12H18N2O3S
化学文摘社编号:
分子量:
270.35
Beilstein:
1984428
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
生物来源
synthetic (organic)
质量水平
等级
analytical standard
方案
97.0-103.0%
技术
HPLC: suitable
gas chromatography (GC): suitable
溶解性
ethanol: 50 mg/mL, clear, colorless
应用
forensics and toxicology
pharmaceutical (small molecule)
包装形式
neat
SMILES字符串
CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1
InChI
1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
InChI key
JLRGJRBPOGGCBT-UHFFFAOYSA-N
基因信息
human ... ABCC8(6833), ALB(213), CYP1A2(1544), CYP2C9(1559), EPHX2(2053), KCNJ1(3758), KCNJ11(3767)
mouse ... Ephx2(13850)
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应用
有关合适仪器技术的更多信息，请参考产品′s分析证书。如需进一步支持，请联系技术服务。
生化/生理作用
抗糖尿病制剂。由CYP2C9（甲苯磺丁脲羟化酶）所代谢。
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Kevin S C Hamming et al.
Diabetes, 59(7), 1686-1693 (2010-04-24)
The sodium-calcium exchanger isoform 1 (NCX1) regulates cytoplasmic calcium (Ca(2+)(c)) required for insulin secretion in beta-cells. NCX1 is alternatively spliced, resulting in the expression of splice variants in different tissues such as NCX1.3 and -1.7 in beta-cells. As pharmacological inhibitors
Ruurdtje Hoekstra et al.
Drug metabolism and disposition: the biological fate of chemicals, 41(3), 562-567 (2012-12-15)
The human liver cell line HepaRG has been recognized as a promising source for in vitro testing of metabolism and toxicity of compounds. However, currently the hepatic differentiation of these cells relies on exposure to dimethylsulfoxide (DMSO), which, as a
Ioannis Eleftherianos et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(29), 12024-12029 (2011-07-02)
The effects of the cellular environment on innate immunity remain poorly characterized. Here, we show that in Drosophila ATP-sensitive potassium channels (K(ATP)) mediate resistance to a cardiotropic RNA virus, Flock House virus (FHV). FHV viral load in the heart rapidly
Jean-Claude Henquin et al.
Diabetes, 62(5), 1689-1696 (2013-01-01)
Congenital hyperinsulinism causes persistent hypoglycemia in neonates and infants. Most often, uncontrolled insulin secretion (IS) results from a lack of functional K(ATP) channels in all β-cells or only in β-cells within a resectable focal lesion. In more rare cases, without
Jingwen Gao et al.
Journal of ethnopharmacology, 145(2), 566-572 (2012-12-05)
Cooked rhubarb and wine processed rhubarb are the processed rhubarbs of raw rhizomes from Rheum palmatum L., Rheum tanguticum Maxim. ex Balf. or Rheum officinale Baill. They are clinically used in traditional Chinese medicine to compose anti-diabetic formulas and remove
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