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T8032

四环素 盐酸盐

powder

别名:

Tetracycline HCL

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关于此项目

经验公式（希尔记法）:
C22H24N2O8 · HCl
化学文摘社编号:
64-75-5
分子量:
480.90
UNSPSC Code:
51284043
NACRES:
NA.76
PubChem Substance ID:
24900496
EC Number:
200-593-8
Beilstein/REAXYS Number:
3844873
MDL number:
MFCD00078142
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biological source

synthetic

Quality Level

200

sterility

γ-irradiated

form

powder

potency

≥850 μg per mg

storage condition

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

color

faintly yellow to yellow

mp

220-223 °C (lit.)

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

protein synthesis | interferes

storage temp.

−20°C

SMILES string

Cl.CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O

InChI

1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1

InChI key

XMEVHPAGJVLHIG-FMZCEJRJSA-N

General description

Chemical structure: tetracycline

Application

建议以 10-20μg/ml 的量用于分子生物学应用。

Biochem/physiol Actions

作用机制：四环素通过细胞膜中的 proin 通道被动扩散，与 30S 核糖体结合，并通过阻止氨酰基 tRNA 进入 mRNA-核糖体复合物上的受体位点来抑制蛋白质合成。它也与细菌的 50S 核糖体亚基结合，改变膜并导致细胞内成分从细菌细胞中泄漏。通过洗涤可以逆转抑制作用，这表明起到抗菌作用的是可逆结合的抗生素，而不是不可逆结合的药物。

耐药性机制：这种作用通过细胞壁通透性的丧失而失活。

抗菌谱：包括对革兰氏阳性和革兰氏阴性细菌的广泛抗菌活性。

Packaging

10MG,20MG

Preparation Note

The product is freely soluble in water, soluble in methanol and ethanol but is insoluble in ether and hydrocarbons. In water, the product yields a clear, yellow-orange solution with heating and in 95% ethanol, 50 mg dissolved in 4 mL with heating yields a clear, yellow-green solution. Tetracycline is rapidly destroyed by alkali hydroxide solutions and standing water solutions become turbid due to hydrolysis and precipitation. The potency of tetracycline is reduced in solutions with pH below 2.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Disclaimer

直接在样品瓶中用无菌水 (10mg/ml) 制备储存液。储存液在 2-8°C 下保存不应超过一周；四环素在水溶液中会发生水解。

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Warning

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

涉药品监管产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000481214
0000481213
0000481214
0000481213
SLCN7482

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Structure (London, England : 1993), 28(9), 1004-1013 (2020-05-30)
Despite high-resolution crystal structures of both inactive and active G protein-coupled receptors (GPCRs), it is still not known how ligands trigger the large structural change on the intracellular side of the receptor since the conformational changes that occur within the
Trevor Y H Ho et al.
Nature communications, 12(1), 2200-2200 (2021-04-15)
Split inteins are powerful tools for seamless ligation of synthetic split proteins. Yet, their use remains limited because the already intricate split site identification problem is often complicated by the requirement of extein junction sequences. To address this, we augment
Ruiling Qi et al.
Colloids and surfaces. B, Biointerfaces, 110, 148-155 (2013-05-29)
Fabrication of nanofiber-based drug delivery system with controlled release property is of general interest in biomedical sciences. In this study, we prepared an antibiotic drug tetracycline hydrochloride (TCH)-loaded halloysite nanotubes/poly(lactic-co-glycolic acid) composite nanofibers (TCH/HNTs/PLGA), and evaluated the drug release and
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全球贸易项目编号

货号GTIN
T8032-20MG04061837378829
T8032-10MG04061837378812