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Merck
CN

V8388

长春新碱 硫酸酯

meets USP testing specifications

别名:

长春新碱 硫酸盐, VCR, 醛基长春碱 硫酸盐, 长春醛碱 硫酸盐

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关于此项目

经验公式（希尔记法）:
C46H56N4O10 · H2SO4
化学文摘社编号:
2068-78-2
分子量:
923.04
UNSPSC Code:
12352210
NACRES:
NA.21
PubChem Substance ID:
24900771
EC Number:
218-190-0
Beilstein/REAXYS Number:
3924631
MDL number:
MFCD00084729

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产品名称

长春新碱 硫酸酯, meets USP testing specifications

InChI key

AQTQHPDCURKLKT-PNYVAJAMSA-N

InChI

1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1

SMILES string

OS(O)(=O)=O.CC[C@]1(O)CC2CN(CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)C7[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67C89)C(=O)OC)C1

agency

USP/NF
meets USP testing specifications

solubility

ethanol: slightly soluble
methanol: soluble
water: freely soluble

antibiotic activity spectrum

neoplastics

application(s)

pharmaceutical (small molecule)

mode of action

protein synthesis | interferes

storage temp.

−20°C

Quality Level

200

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相关类别

Application

use product name over-ride for USP name - jk 6/2/2005
Vincristine sulfate has been used:
  • as a positive control in potato disc anti-tumor bioassay
  • as a standard cytotoxic agent
  • to treat cells for manipulation of the microtubule network

Biochem/physiol Actions

Vincristine sulfate possesses antitumor action targeting cell cycle. It prevents the action of tubulin by inhibiting microtubule polymerization. It also causes cell death and blocks metaphase in mitosis by preventing chromosome segregation. Vincristine sulfate inhibits angiogenesis mediated by factors such as vasculature endothelial growth factor. It decreases vascularization in tumors and normal tissues.

General description

Vincristine sulfate is an alkaloid present in Cantharanthus roseus.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Muta. 2 - Repr. 2

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000453617
0000453617
0000389773
0000332138
0000308038

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