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Merck
CN

X4251

XTT 钠盐

analytical standard, ≥90%

别名:

2,3-双(2-甲氧基-4-硝基-5-磺苯基)-2H-四氮唑-5-甲酰苯胺 内盐

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关于此项目

经验公式（希尔记法）:
C22H16N7NaO13S2
化学文摘社编号:
111072-31-2
分子量:
673.52
NACRES:
NA.24
PubChem Substance ID:
329830806
UNSPSC Code:
41116107
MDL number:
MFCD00083517

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产品名称

XTT 钠盐, analytical standard, ≥90%

InChI

1S/C22H17N7O13S2.Na/c1-41-17-8-15(28(31)32)19(43(35,36)37)10-13(17)26-24-21(22(30)23-12-6-4-3-5-7-12)25-27(26)14-11-20(44(38,39)40)16(29(33)34)9-18(14)42-2;/h3-11H,1-2H3,(H2-,23,30,35,36,37,38,39,40);/q;+1/p-1

SMILES string

[Na+].COc1cc(c(cc1-n2nc(n[n+]2-c3cc(c(cc3OC)[N+]([O-])=O)S([O-])(=O)=O)C(=O)Nc4ccccc4)S([O-])(=O)=O)[N+]([O-])=O

InChI key

JACYMBNQPPWQML-UHFFFAOYSA-M

grade

analytical standard

assay

≥90%

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

100

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相关类别

Application

XTT可与吩嗪硫酸甲酯（PMS）联合使用，用于筛选人肿瘤细胞系。 四唑染料也被用于真菌细胞损伤研究 、葡萄球菌的抗菌敏感性测试，以及念珠菌生物膜研究。XTT检测法的局限性也有报道。
可用于艾滋病和癌症检测。
有关合适的仪器技术的更多信息，请参阅产品′的分析证书。联系技术服务部以获得进一步支持。

Biochem/physiol Actions

在活细胞中，XTT被代谢还原，生成可比色的水溶性甲臜产物。

pictograms

Flame
GHS02

signalword

Danger

hcodes

H242

Hazard Classifications

Self-react. C

supp_hazards

EUH044

存储类别

4.1A - Other explosive hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLCB8867
SLCB3746
SLCB3752
SLCB3757
SLBZ5370

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Parsons, J.L., et al.
Journal of Heterocyclic Chemistry, 25, 911-911 (1988)
Wander José da Silva et al.
Brazilian dental journal, 19(4), 364-369 (2009-01-31)
2, 3-bis (2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino) carbonyl]-2H-tetrazolium hydroxide (XTT) reduction assay has been used to study Candida biofilm formation. However, considering that the XTT reduction assay is dependent on cell activity, its use for evaluating mature biofilms may lead to inaccuracies since biofilm
D A Scudiero et al.
Cancer research, 48(17), 4827-4833 (1988-09-01)
We have previously described the application of an automated microculture tetrazolium assay (MTA) involving dimethyl sulfoxide solubilization of cellular-generated 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)-formazan to the in vitro assessment of drug effects on cell growth (M.C. Alley et al., Proc. Am. Assoc.
Cristina Sánchez-Quesada et al.
Evidence-based complementary and alternative medicine : eCAM, 2018, 9473094-9473094 (2018-10-27)
Anti-inflammatory effects of virgin olive oil (VOO) have been described recently, along with its wound healing effect. One of the main minor compounds found in VOO is squalene (SQ), which also possesses preventive effects against skin damage and anti-inflammatory properties.

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