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经验公式（希尔记法）:
C16H25NO2 · HCl
化学文摘社编号:
分子量:
299.84
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
format
neat
InChI
1S/C16H25NO2.ClH/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3;/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3;1H/t14-,16+;/m1./s1
SMILES string
Cl.COc1cccc(c1)[C@@]2(O)CCCC[C@@H]2CN(C)C
InChI key
PPKXEPBICJTCRU-XMZRARIVSA-N
grade
pharmaceutical primary standard
API family
tramadol
manufacturer/tradename
EDQM
drug control
USDEA Schedule IV
application(s)
pharmaceutical (small molecule)
storage temp.
2-8°C
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Tramadol is a synthetic opiate agonist analgesic, widely used in patients suffering from moderate to severe chronic pain. It is considered safe when compared to other opioids. It contributes to the analgesic activity by blocking the nociceptive impulses at the spinal level, inhibiting the norepinephrine and serotonin reuptake.
Tramadol is a synthetic opiate agonist analgesic, widely used in patients suffering from moderate to severe chronic pain. It is considered safe when compared to other opioids. It contributes to the analgesic activity by blocking the nociceptive impulses at the spinal level, inhibiting the norepinephrine and serotonin reuptake.
Application
This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.
Biochem/physiol Actions
Opioid analgesic; P450 substrate.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 2 - STOT SE 3
target_organs
Central nervous system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
Analgesic oral efficacy of tramadol hydrochloride in postoperative pain
Sunshine A, et al.
Clinical Pharmacology and Therapeutics, 51(6), 740-746 (1992)
Kinetic spectrophotometric determination of tramadol hydrochloride in pharmaceutical formulation
Abdellatef EH
Journal of Pharmaceutical and Biomedical Analysis, 29(5), 835-842 (2002)
Application of HPLC for the simultaneous determination of aceclofenac, paracetamol and tramadol hydrochloride in pharmaceutical dosage form
Chandra P, et al.
Scientia Pharmaceutica, 80(2), 337-352 (2012)
The clinical use of tramadol hydrochloride
Bamigbade AT and Langford MR
Pain, 5(6), 155-182 (1998)
HPLC determination and validation of tramadol hydrochloride in capsules
Kartinasari FW, et al.
Journal of Liquid Chromatography and Related Technologies, 27(4), 737-744 (2004)
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