SMILES string
[s]1c2c(cc1Br)C(=NCc4[n]2c(nn4)C)c3c(cccc3)Cl
InChI
1S/C15H10BrClN4S/c1-8-19-20-13-7-18-14(9-4-2-3-5-11(9)17)10-6-12(16)22-15(10)21(8)13/h2-6H,7H2,1H3
InChI key
UMSGKTJDUHERQW-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
brotizolam
manufacturer/tradename
EDQM
drug control
kontrollierte Droge in Deutschland, psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Brotizolam EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
Legal Information
German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.
English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.
English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.
法规信息
新产品
此项目有
Xiaolei Yan et al.
International journal of psychiatry in clinical practice, 17(4), 239-243 (2012-10-03)
To investigate the efficacy and safety of brotizolam in outpatients with insomnia. This randomized, double-blind, double-dummy, multicenter, controlled trial recruited 253 outpatients randomized to receive either brotizolam (n = 126) or estazolam (n = 127) for 14 days followed by
Hee-Jung Cho et al.
Biomedical chromatography : BMC, 25(9), 1061-1066 (2011-03-15)
In this work, a liquid chromatography-tandem mass spectrometric detection technique was developed and validated for the determination of brotizolam residues in beef muscle and commercial whole milk. This procedure involves the extraction of the analyte from the samples via liquid-solid
Marian Weisenberg et al.
Journal of clinical anesthesia, 22(3), 190-195 (2010-04-20)
To determine a propofol dose that minimizes hemodynamic changes on induction of anesthesia in patients chronically taking angiotensin-converting enzyme inhibitors (ACEIs). Prospective, randomized trial. Operating room of a university-affiliated general hospital. 88 ASA physical status II and II hypertensive patients
Takaki Tokairin et al.
British journal of clinical pharmacology, 60(2), 172-175 (2005-07-27)
To obtain in vivo evidence for the involvement of cytochrome P450 (CYP) 3A4 in the metabolism of brotizolam. Fourteen healthy male volunteers received erythromycin 1200 mg day(-1) or placebo for 7 days in a double-blind randomized crossover manner. On the
Shlomit Jacobson-Pick et al.
The international journal of neuropsychopharmacology, 11(7), 891-903 (2008-03-28)
Profound evidence indicates that GABAA receptors are important in the control of physiological response to stress and anxiety. The alpha subunit type composition contributes significantly to the functional characterization of the GABAA receptors. The alpha2, alpha3, alpha5 subunits are predominately
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