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文件

Y0000688

氯雷他定

Name: 氯雷他定
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

4-（8-氯-5,6-二氢-11H-苯并[5,6]环庚[1,2-b]吡啶-11-亚基-1-哌啶羧酸乙酯, 氯雷他定

经验公式（希尔记法）:

C₂₂H₂₃N₂O₂Cl

CAS号:

79794-75-5

分子量:

382.88

MDL编号:

MFCD00672869

PubChem化学物质编号:

329831098

NACRES:

NA.24

等级

pharmaceutical primary standard

API family

loratadine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

CCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24

InChI

1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3

InChI key

JCCNYMKQOSZNPW-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Loratadine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

非镇静组胺H₁-受体拮抗剂。

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

1370280

地氯雷他定, United States Pharmacopeia (USP) Reference Standard

1370270

氯雷他定, United States Pharmacopeia (USP) Reference Standard

1370291

1370269

BP874

氯雷他定, British Pharmacopoeia (BP) Reference Standard

BP875

氯雷他定, British Pharmacopoeia (BP) Reference Standard

PHR2308

Loratadine Related Compound B

PHR2309

PHR2313

N-乙氧羰基-4-哌啶酮, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2310

Loratadine Impurity A, certified reference material, pharmaceutical secondary standard

PHR2311

Loratadine Impurity E, Pharmaceutical Secondary Standard; Certified Reference Material

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

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705578-5MG-PW

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1000309185

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索取COA

Neuroleptic malignant syndrome induced by haloperidol following traumatic brain injury.

R Wilkinson et al.

Brain injury, 13(12), 1025-1031 (2000-01-11)

The use of neuroleptics in the acute management of traumatic brain injury (TBI) is controversial and may be detrimental to recovery. The following case report describes a patient developing neuroleptic malignant syndrome (NMS) secondary to the use of haloperidol given

Solubility enhancement of desloratadine by solid dispersion in poloxamers.

Nemanja Kolašinac et al.

International journal of pharmaceutics, 436(1-2), 161-170 (2012-07-10)

The present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of the poorly water soluble drug substance desloratadine that can be used for the preparation of immediate release tablet formulation. Two commercially available poloxamer

Therapeutic brain concentration of the NMDA receptor antagonist amantadine.

J Kornhuber et al.

Neuropharmacology, 34(7), 713-721 (1995-07-01)

Amantadine (1-amino-adamantane) is clinically used for the management of Parkinson's disease and drug-induced extrapyramidal symptoms. It has previously been shown that amantadine is a low-affinity uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist with rapid blocking and unblocking channel kinetics (Ki-value at the

Molecularly imprinted nano particles combined with miniaturized homogenous liquid-liquid extraction for the selective extraction of loratadine in plasma and urine samples followed by high performance liquid chromatography-photo diode array detection.

H Ebrahimzadeh et al.

Analytica chimica acta, 767, 155-162 (2013-03-05)

In this work a molecularly imprinted polymer was developed as a selective sorbent for extraction of loratadine (as a model) in complex matrices followed by miniaturized homogeneous liquid-liquid extraction (MHLLE) for the first time. The molecularly imprinted polymer (MIP) which

Stimulation of dopa decarboxylase activity in striatum of healthy human brain secondary to NMDA receptor antagonism with a low dose of amantadine.

P Deep et al.

Synapse (New York, N.Y.), 34(4), 313-318 (1999-10-26)

The efficacy of amantadine in alleviating motor symptoms of Parkinson's disease may be mediated in part by stimulation of cerebral dopa decarboxylase (DDC) activity, secondary to antagonism of N-methyl-D-aspartate (NMDA) type glutamate receptors. We tested the specific hypothesis that amantadine

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