Merck
CN

Y0000789

盐酸非索非那定 盐酸盐

European Pharmacopoeia (EP) Reference Standard

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别名:
MDL 16455 盐酸盐, 羧酸非索芬那定 盐酸盐, 非索芬那定 盐酸盐
Empirical Formula (Hill Notation):
C32H39NO4 · HCl
分子量:
538.12
MDL编号:
PubChem化学物质编号:
NACRES:
NA.24

等级

pharmaceutical primary standard

API family

fexofenadine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

Cl[H].CC(C)(C(O)=O)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4

InChI

1S/C32H39NO4.ClH/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27;/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36);1H

InChI key

RRJFVPUCXDGFJB-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

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此商品
BP1095F9427PHR1685
Fexofenadine hydrochloride European Pharmacopoeia (EP) Reference Standard

Y0000789

盐酸非索非那定 盐酸盐

Fexofenadine hydrochloride British Pharmacopoeia (BP) Reference Standard

BP1095

盐酸非索非那定 盐酸盐

Fexofenadine HCl Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1685

盐酸非索非那定

manufacturer/tradename

EDQM

manufacturer/tradename

BP

manufacturer/tradename

-

manufacturer/tradename

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical

application(s)

-

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

-

format

neat

API family

fexofenadine

API family

fexofenadine

API family

-

API family

fexofenadine

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-30°C

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Fexofenadine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

非索非那定是一种非镇静性 H1 组胺受体拮抗剂。

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Erik Sjögren et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 57, 214-223 (2013-10-01)
The pharmacokinetics (PK) of fexofenadine (FEX) in pigs were investigated with the focus on exploring the interplay between hepatic transport and metabolism when administered intravenously (iv) alone or with verapamil. The in vivo pig model enabled simultaneous sampling from plasma
Takayo Haruna et al.
Pharmacology, 95(1-2), 95-103 (2015-02-28)
We have previously reported that S-777469 [1-([6-ethyl-1-(4-fluorobenzyl)-5-methyl-2-oxo-1,2-dihydropyridine-3-carbonyl]amino)-cyclohexanecarboxylic acid], a novel cannabinoid type 2 receptor (CB2) agonist, significantly suppressed compound 48/80-induced scratching behavior in mice in a dose-dependent manner when it was administered orally. Here, we demonstrated that the inhibitory effects
Shigeru Hishinuma et al.
Biochemical pharmacology, 91(2), 231-241 (2014-07-30)
Differential binding sites for first- and second-generation antihistamines were indicated on the basis of the crystal structure of human histamine H1 receptors. In this study, we evaluated differences between the thermodynamic driving forces of first- and second-generation antihistamines for human
Yoshiyuki Shirasaka et al.
Pharmaceutical research, 31(8), 2035-2043 (2014-02-20)
OATP2B1-mediated grapefruit juice (GFJ)-drug interactions are substrate-dependent; for example, GFJ ingestion significantly reduces bioavailability of fexofenadine, but not pravastatin. In the present study, we aimed to establish whether this observation can be explained by the presence of multiple binding sites
Jung Yeon Kim et al.
Biomedical chromatography : BMC, 29(3), 465-474 (2014-08-01)
The purpose of this study was to develop and validate an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistamines (illegal additives) in dietary supplements. The limits of detection and quantitation of the method ranged from 1.5 to 2.5

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