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文件

Y0000789

盐酸非索非那定盐酸盐

Name: 盐酸非索非那定 盐酸盐
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

MDL 16455 盐酸盐, 羧酸非索芬那定盐酸盐, 非索芬那定盐酸盐

经验公式（希尔记法）:

C₃₂H₃₉NO₄ · HCl

CAS号:

153439-40-8

分子量:

538.12

MDL编号:

MFCD00865710

PubChem化学物质编号:

329831152

NACRES:

NA.24

等级

pharmaceutical primary standard

API类

fexofenadine

制造商/商品名称

EDQM

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES字符串

Cl[H].CC(C)(C(O)=O)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4

InChI

1S/C32H39NO4.ClH/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27;/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36);1H

InChI key

RRJFVPUCXDGFJB-UHFFFAOYSA-N

基因信息

human ... HRH1(3269)

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Fexofenadine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

非索非那定是一种非镇静性 H1 组胺受体拮抗剂。

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

1270377

盐酸非索非那定盐酸盐, United States Pharmacopeia (USP) Reference Standard

1270446

1270399

1270388

PHR2454

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

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Effects of verapamil on the pharmacokinetics and hepatobiliary disposition of fexofenadine in pigs.

Erik Sjögren et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 57, 214-223 (2013-10-01)

The pharmacokinetics (PK) of fexofenadine (FEX) in pigs were investigated with the focus on exploring the interplay between hepatic transport and metabolism when administered intravenously (iv) alone or with verapamil. The in vivo pig model enabled simultaneous sampling from plasma

S-777469, a novel cannabinoid type 2 receptor agonist, suppresses itch-associated scratching behavior in rodents through inhibition of itch signal transmission.

Takayo Haruna et al.

Pharmacology, 95(1-2), 95-103 (2015-02-28)

We have previously reported that S-777469 [1-([6-ethyl-1-(4-fluorobenzyl)-5-methyl-2-oxo-1,2-dihydropyridine-3-carbonyl]amino)-cyclohexanecarboxylic acid], a novel cannabinoid type 2 receptor (CB2) agonist, significantly suppressed compound 48/80-induced scratching behavior in mice in a dose-dependent manner when it was administered orally. Here, we demonstrated that the inhibitory effects

Differential thermodynamic driving force of first- and second-generation antihistamines to determine their binding affinity for human H1 receptors.

Shigeru Hishinuma et al.

Biochemical pharmacology, 91(2), 231-241 (2014-07-30)

Differential binding sites for first- and second-generation antihistamines were indicated on the basis of the crystal structure of human histamine H1 receptors. In this study, we evaluated differences between the thermodynamic driving forces of first- and second-generation antihistamines for human

Development and validation of an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistaminics in dietary supplements.

Jung Yeon Kim et al.

Biomedical chromatography : BMC, 29(3), 465-474 (2014-08-01)

The purpose of this study was to develop and validate an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistamines (illegal additives) in dietary supplements. The limits of detection and quantitation of the method ranged from 1.5 to 2.5

Using improved serial blood sampling method of mice to study pharmacokinetics and drug-drug interaction.

Ayahisa Watanabe et al.

Journal of pharmaceutical sciences, 104(3), 955-961 (2014-12-03)

In pharmacokinetic evaluation of mice, using serial sampling methods rather than a terminal blood sampling method could reduce the number of animals needed and lead to more reliable data by excluding individual differences. In addition, using serial sampling methods can

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盐酸非索非那定 盐酸盐