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经验公式（希尔记法）:
C21H23NO4S
化学文摘社编号:
分子量:
385.48
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI key
ODUOJXZPIYUATO-UHFFFAOYSA-N
SMILES string
CC(=O)SCC(Cc1ccccc1)C(=O)NCC(=O)OCc2ccccc2
InChI
1S/C21H23NO4S/c1-16(23)27-15-19(12-17-8-4-2-5-9-17)21(25)22-13-20(24)26-14-18-10-6-3-7-11-18/h2-11,19H,12-15H2,1H3,(H,22,25)
grade
pharmaceutical primary standard
API family
racecadotril
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Racecadotril for peak identification EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Biochem/physiol Actions
Neutral endopeptidase inhibitor; antidiarrheal
Racecadotril is a neutral endopeptidase inhibitor, an antidiarrheal drug which acts as a peripherally acting enkephalinase inhibitor.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
J C Schwartz
International journal of antimicrobial agents, 14(1), 75-79 (2000-03-16)
Since enkephalins were discovered in 1975, it has become clear that they play an antisecretory role in the gastrointestinal tract. Hence a rational research programme was directed at the development of a drug that would preserve these neurotransmitter peptides in
A J Matheson et al.
Drugs, 59(4), 829-835 (2000-05-10)
Racecadotril is an oral enkephalinase inhibitor used in the treatment of acute diarrhoea. It prevents the degradation of endogenous opioids (enkephalins), thereby reducing hypersecretion of water and electrolytes into the intestinal lumen. In a randomised double-blind study in 6 adult
H Szajewska et al.
Alimentary pharmacology & therapeutics, 26(6), 807-813 (2007-09-05)
Racecadotril (acetorphan) is an antisecretory drug that exerts its antidiarrhoeal effects by inhibiting intestinal enkephalinase. To summarize studies testing the efficacy and safety of racecadotril for treating children with acute gastroenteritis. Reports were gathered by searching electronic databases MEDLINE, EMBASE
S Huighebaert et al.
Digestive diseases and sciences, 48(2), 239-250 (2003-03-20)
Racecadotril is an enkephalinase inhibitor, presented as a purely antisecretory agent with advantages over the opiate-receptor agonist loperamide in the treatment of diarrhea. A critical review of the literature and the models used was performed. Although pretreatment with high doses
J I Emparanza Knörr et al.
Anales de pediatria (Barcelona, Spain : 2003), 69(5), 432-438 (2009-01-09)
To estimate, through a systematic review of the literature, the efficacy of racecadotril in the treatment of acute diarrhoea. Randomised trials carried out in children comparing racecadotril with placebo in terms of diarrhoea recovery, stools output and adverse effects were
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