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文件

Y0001015

诺氟沙星

Name: 诺氟沙星
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

1-乙基-6-氟-1,4-二氢-4-氧代-7-(1-哌嗪基)-3-喹啉羧酸, 1-乙基-6-氟-1,4-二氢-4-氧代-7-哌嗪-3-喹啉羧酸

经验公式（希尔记法）:

C₁₆H₁₈FN₃O₃

CAS号:

70458-96-7

分子量:

319.33

MDL编号:

MFCD00079532

PubChem化学物质编号:

329831219

NACRES:

NA.24

等级

pharmaceutical primary standard

API类

norfloxacin

制造商/商品名称

EDQM

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES字符串

CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCNCC3

InChI

1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)

InChI key

OGJPXUAPXNRGGI-UHFFFAOYSA-N

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Norfloxacin for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

诺氟沙星通过干扰 ATP 诱导转换 DNA 与 DNA 旋转酶（拓扑异构酶）复合物的结构转换而阻断 DNA 复制。
操作方式：抑制细菌 DNA 复制
抗菌谱：革兰氏阴性菌；对革兰氏阳性菌效果较差

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

1471517

1471550

1471583

1471619

PHR1614

诺氟沙星, Pharmaceutical Secondary Standard; Certified Reference Material

BP670

诺氟沙星, British Pharmacopoeia (BP) Reference Standard

PHR2233

象形图

GHS07

警示用语：

Warning

危险声明

H319

预防措施声明

P264 - P280 - P305 + P351 + P338 - P337 + P313

危险分类

Eye Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 2

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

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In vitro antimicrobial activity of hydroxypyridinone hexadentate-based dendrimeric chelators alone and in combination with norfloxacin.

Ying-Jun Zhou et al.

FEMS microbiology letters, 355(2), 124-130 (2014-05-13)

The antimicrobial activity of one 3-hydroxypyridin-4-one (HPO) hexadentate (1) and three HPO hexadentate-based dendrimeric chelators (2-4) was evaluated. They were found to exhibit marked inhibitory effect on the growth of two Gram-positive bacteria and two Gram-negative bacteria. The combination treatment

Review of norfloxacin in lower urinary tract infections.

L Miano et al.

European urology, 17 Suppl 1, 13-18 (1990-01-01)

A review of worldwide clinical trials with norfloxacin in the treatment of uncomplicated urinary tract infections (UTIs), as well as our personal experience with 215 assessable patients, is presented. Almost all patients received 400 mg b.i.d. for 3-15 days. Bacteriological

Bacterial resistance to norfloxacin and other newer quinolones: pattern and prospects.

D R Nalin

European journal of cancer & clinical oncology, 24 Suppl 1, S55-S61 (1988-01-01)

Norfloxacin, a fluoroquinolone antibacterial agent. Classification, mechanism of action, and in vitro activity.

E J Goldstein

The American journal of medicine, 82(6B), 3-17 (1987-06-26)

Norfloxacin is an orally absorbed fluoroquinolone antibacterial with a fluorine at position 6 and a piperazine ring at position 7. These changes have resulted in a marked enhancement (compared with that of the older quinolones) of in vitro antibacterial activity.

Expression of homologous RND efflux pump genes is dependent upon AcrB expression: implications for efflux and virulence inhibitor design.

Jessica M A Blair et al.

The Journal of antimicrobial chemotherapy, 70(2), 424-431 (2014-10-08)

Enterobacteriaceae have multiple efflux pumps that confer intrinsic resistance to antibiotics. AcrB mediates clinically relevant multidrug resistance and is required for virulence and biofilm formation, making it an attractive target for the design of inhibitors. The aim of this study

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