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文件

Y0001025

盐酸贝那普利盐酸盐

Name: 盐酸贝那普利 盐酸盐
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

(3S)-3-[[(1S)-1-(乙氧羰基)-3-苯丙基]氨基]-2,3,4,5-四氢-2-氧代-1H-1-苯并氮杂卓-1-乙酸盐酸盐

经验公式（希尔记法）:

C₂₄H₂₈N₂O₅ · HCl

CAS号:

86541-74-4

分子量:

460.95

MDL编号:

MFCD00895734

PubChem化学物质编号:

329831225

NACRES:

NA.24

等级

pharmaceutical primary standard

API family

benazepril

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

Cl[H].CCOC(=O)[C@H](CCc1ccccc1)N[C@H]2CCc3ccccc3N(CC(O)=O)C2=O

InChI

1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);1H/t19-,20-;/m0./s1

InChI key

VPSRQEHTHIMDQM-FKLPMGAJSA-N

Gene Information

human ... ACE(1636)

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Benazepril hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

贝那普利是一种长效的血管紧张素转换酶 (ACE) 抑制剂。

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

Y0001038

盐酸贝那普利盐酸盐, European Pharmacopoeia (EP) Reference Standard

Y0001026

贝那普利杂质A, European Pharmacopoeia (EP) Reference Standard

1048685

1048674

(S)-3-氨基-四氢-2-氧-1-苯并氮杂卓-1-乙酸叔丁酯, United States Pharmacopeia (USP) Reference Standard

1048620

1048619

盐酸贝那普利盐酸盐, United States Pharmacopeia (USP) Reference Standard

1048652

1048663

1048641

1048630

PHR1912

盐酸贝那普利, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2422

PHR2423

(S)-3-氨基-四氢-2-氧-1-苯并氮杂卓-1-乙酸叔丁酯, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2922

PHR2930

PHR8937

PHR8936

象形图

GHS08

警示用语：

Warning

危险声明

H361fd

预防措施声明

P201 - P202 - P280 - P308 + P313 - P405 - P501

危险分类

Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

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Simultaneous determination of benazepril hydrochloride and hydrochlorothiazide in tablets by second-order derivative spectrophotometry.

Panderi E I.

Journal of Pharmaceutical and Biomedical Analysis, 21(2), 257-265 (1999)

Application of LC and HPTLC-densitometry for the simultaneous determination of benazepril hydrochloride and hydrochlorothiazide.

El-Gindy A, et al.

Journal of Pharmaceutical and Biomedical Analysis, 25(2), 171-179 (2001)

Liquid chromatography-tandem mass spectrometry method for determination of aliskiren in saliva and its application to a clinical trial with healthy volunteers.

Bjoern B Burckhardt et al.

Journal of pharmaceutical and biomedical analysis, 96, 118-126 (2014-04-18)

Although serum and plasma are the biological fluids of choice for pharmacokinetic determination of drugs in adults, it is desirable to elucidate noninvasive methods which can be used for investigations in vulnerable groups such as children. If the drug properties

Simultaneous quantitative and qualitative analysis of aliskiren, enalapril and its active metabolite enalaprilat in undiluted human urine utilizing LC-ESI-MS/MS.

Bjoern B Burckhardt et al.

Biomedical chromatography : BMC, 28(12), 1679-1691 (2014-05-03)

The benefit-risk ratio of combined blocking by the direct renin inhibitor aliskiren and an angiotensin-converting enzyme inhibitor (e.g. enalapril) on the renin-angiotensin-aldosterone system is discussed. No method was available for simultaneous determination of both drugs in urine. A novel sensitive

Hepatic, intestinal, renal, and plasma hydrolysis of prodrugs in human, cynomolgus monkey, dog, and rat: implications for in vitro-in vivo extrapolation of clearance of prodrugs.

Haruka Nishimuta et al.

Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1522-1531 (2014-07-06)

Hydrolysis plays an important role in metabolic activation of prodrugs. In the current study, species and in vitro system differences in hepatic and extrahepatic hydrolysis were investigated for 11 prodrugs. Ten prodrugs in the data set are predominantly hydrolyzed by

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盐酸贝那普利 盐酸盐