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经验公式（希尔记法）:
C6H11NO2
化学文摘社编号:
分子量:
129.16
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
产品名称
氨己烯酸, European Pharmacopoeia (EP) Reference Standard
InChI
1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9)
SMILES string
NC(CCC(O)=O)C=C
InChI key
PJDFLNIOAUIZSL-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
vigabatrin
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Gene Information
human ... ABAT(18)
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Biochem/physiol Actions
不可逆的 GABA 转氨酶抑制剂。增加神经末梢的胞内 GABA 浓度；具有抗癫痫活性。
Application
Vigabatrin EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
signalword
Danger
hcodes
Hazard Classifications
STOT RE 1
target_organs
Eyes,Central nervous system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
E Faught
Acta neurologica Scandinavica. Supplementum, (192)(192), 29-35 (2011-11-09)
Vigabatrin is an antiepileptic drug used in more than 50 countries as adjunctive therapy for the treatment of refractory complex partial seizures (rCPS) in adults. First approved in the United Kingdom in 1989, vigabatrin was approved for use in the
Harinder Jaseja
Clinical neurology and neurosurgery, 111(2), 111-114 (2008-10-11)
West syndrome (WS) or infantile spasms (IS) is a severe epileptic syndrome associated with poor prognosis and increased morbidity. The exact etio-pathogenesis of the disorder still remains elusive ant therefore the management continues to pose a challenge to the clinicians.
Kimberly A Pesaturo et al.
Pharmacotherapy, 31(3), 298-311 (2011-03-03)
Infantile spasms describe a pediatric epilepsy syndrome characterized by frequent clusters of brief symmetric muscle contractions; the condition is often associated with developmental delay. When infantile spasms are accompanied by hypsarrhythmia on electroencephalogram, the condition is labeled West syndrome. The
Robert C Sergott
Current opinion in ophthalmology, 21(6), 442-446 (2010-09-03)
Although vigabatrin has been used for many years in Europe, this antiepileptic medication was approved for use in the USA only 1 year ago because of concerns for irreversible peripheral visual field loss that can result in functional visual disability.
R C Sergott et al.
Acta neurologica Scandinavica. Supplementum, (192)(192), 48-56 (2011-11-09)
Vigabatrin, an irreversible inhibitor of γ-aminobutyric acid transaminase, is an antiepileptic drug indicated in the United States as adjunctive therapy for adult patients with refractory complex partial seizures who have responded inadequately to several alternative treatments and for monotherapy treatment
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