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文件

Y0001404

氨己烯酸杂质D

European Pharmacopoeia (EP) Reference Standard

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别名:
γ-氨基丁酸, 3-羧丙胺, 4-氨基丁酸, GABA, 哌啶酸, 氨酪酸
线性分子式:
NH2(CH2)3COOH
CAS号:
56-12-2
分子量:
103.12
Beilstein:
906818
MDL编号:
MFCD00008226
PubChem化学物质编号:
329831405
NACRES:
NA.24

等级

pharmaceutical primary standard

API类

vigabatrin

制造商/商品名称

EDQM

mp

195 °C (dec.) (lit.)

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES字符串

NCCCC(O)=O

InChI

1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)

InChI key

BTCSSZJGUNDROE-UHFFFAOYSA-N

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相关类别

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Vigabatrin impurity D EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

大脑中的主要抑制性神经递质；GABAA 和 GABAB 受体激动剂；增加 Cl− 的传导性。

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Jesse Jackson et al.
Nature neuroscience, 17(10), 1362-1370 (2014-09-01)
Activity flow through the hippocampus is thought to arise exclusively from unidirectional excitatory synaptic signaling from CA3 to CA1 to the subiculum. Theta rhythms are important for hippocampal synchronization during episodic memory processing; thus, it is assumed that theta rhythms
Hussein A N Al-Wadei et al.
Molecular nutrition & food research, 55(12), 1745-1758 (2011-08-02)
GABA is a bioactive constituent of fruits, vegetables, cereals and is believed to play a role in defense against stress in plants. In animals, it acts as an inhibitory neurotransmitter in brain while also expressed in non-neuronal cells. Studies have
T Clayton et al.
Current medicinal chemistry, 14(26), 2755-2775 (2007-11-30)
A successful unified pharmacophore/receptor model which has guided the synthesis of subtype selective compounds is reviewed in light of recent developments both in ligand synthesis and structural studies of the binding site itself. The evaluation of experimental data in combination
W-Y Lu et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 39(7), 956-961 (2009-04-30)
Asthma often occurs as a result of immune-based inflammatory responses, which consequently cause pathological changes in airway structural cells. However, the underlying mechanisms of airway pathology in asthma are still not fully understood. Our recent studies revealed a critical role
Sahar Farajnia et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(26), 9627-9632 (2014-07-01)
The balance between excitation and inhibition is essential for the proper function of neuronal networks in the brain. The inhibitory neurotransmitter γ-aminobutyric acid (GABA) contributes to the network dynamics within the suprachiasmatic nucleus (SCN), which is involved in seasonal encoding.
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