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Merck
CN

T6508

三氟乙酸

ReagentPlus®, 99%

别名:

TFA

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关于此项目

线性分子式:
CF3COOH
化学文摘社编号:
76-05-1
分子量:
114.02
UNSPSC Code:
12352106
NACRES:
NA.21
PubChem Substance ID:
329826846
EC Number:
200-929-3
Beilstein/REAXYS Number:
742035
MDL number:
MFCD00004169

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产品名称

三氟乙酸, ReagentPlus®, 99%

InChI

1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)

SMILES string

OC(C(F)(F)F)=O

InChI key

DTQVDTLACAAQTR-UHFFFAOYSA-N

vapor density

3.9 (vs air)

vapor pressure

97.5 mmHg ( 20 °C)

product line

ReagentPlus®

assay

99%

form

liquid

Quality Level

200

concentration

99%

impurities

≤0.05% water

refractive index

n20/D 1.3 (lit.)

pH

1 (10 g/L)

bp

72.4 °C (lit.)

mp

−15.4 °C (lit.)

solubility

ethanol: soluble 0.33 mL/mL

density

1.489 g/mL at 20 °C (lit.)

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Application

三氟乙酸可用作以下反应的试剂：      
  • 用于裂解氮氧保护基团，如 N-、N-苄基氧甲基、苯醚、对甲氧基苯醚、对丁基醚、对丁基氧甲基醚、三苯基甲基醚和二甲基缩醛。      
  • 在 Baeyer-Villiger 氧化反应中与过碳酸钠结合。，
  • 芳烃的 C-H 三氟甲基化。

TFA 还可以用作：      
  • 原子转移环化反应和聚合物过程中的溶剂。      
  • 催化剂，在非质子溶剂中通过环己酮肟贝克曼重排法合成 ε-己内酰胺。

General description

三氟乙酸（TFA）是一种有机氟化合物，在有机合成中用作各种酸催化反应的试剂，如环氧化合物开环、仿生环化、Cope 重排和天然产物合成。由于 TFA 的高挥发性、在有机溶剂中的溶解度和酸性强度，其物理化学特性比其他酸更有优势。当 TFA 用作试剂时，由于极高的挥发性，可以轻松通过蒸发分离产物。挥发性较低的酸，如硫酸或对甲苯磺酸，可能需要中和或萃取处理。
Our biotech solvents offer exceptional quality for reliable RNA extraction, ensuring optimal laboratory performance. With low water content and minimal residue, give clean UV spectra to minimize contamination.
  • High-Quality Biotech Solvents: Designed for optimal laboratory performance with low water content and minimal residues.
  • Ideal for RNA Extraction: Essential for genetic testing and research applications like PCR.
  • Ensures Integrity of Genetic Material: Promotes reliable and reproducible results.
  • Industry Compliant: Suitable for both academic and commercial laboratories, enhancing research efficiency.

Packaging

每支安瓶中1 mL。

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

存储类别

8A - Combustible corrosive hazardous materials

wgk

WGK 2

法规信息

危险化学品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCZ7243
MKCZ4783
MKCZ4784
SDBB2365
MKCX2698

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Trifluoroacetic acid: Uses and recent applications in organic synthesis.
Lopez SE and Salazar J.
Journal of Fluorine Chemistry, 156, 73-100 (2013)
Oxidative C-C bond cleavage of N-alkoxycarbonylated cyclic amines by sodium nitrite in trifluoroacetic acid
Onomura O, et al.
Tetrahedron Letters, 49(47), 6728-6731 (2008)
Electronic effects in the acid-promoted deprotection of N-2, 4-dimethoxybenzyl maleimides
Watson DJ, et al.
Tetrahedron Letters, 42(10), 1827-1830 (2001)
Organocatalyzed Beckmann rearrangement of cyclohexanone oxime by trifluoroacetic acid in aprotic solvent
Ronchin L, et al.
Catalysis Communications, 10(2), 251-256 (2008)
Guangfa Shi et al.
Organic letters, 17(1), 38-41 (2014-12-18)
Direct trifluoromethylation of arenes using TFA as the trifluoromethylating reagent was achieved with Ag as the catalyst. This reaction not only provides a new protocol for aryl C-H trifluoromethylation, but the generation of CF3· from TFA may prove useful in
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