03907
噻康唑
97%
别名:
1-[2-[(2-Chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, Thioconazole
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关于此项目
经验公式（希尔记法）:
C16H13Cl3N2OS
化学文摘社编号:
分子量:
387.71
PubChem Substance ID:
UNSPSC Code:
51302325
NACRES:
NA.85
EC Number:
265-973-8
MDL number:
InChI
1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2
InChI key
QXHHHPZILQDDPS-UHFFFAOYSA-N
assay
≥96.5% (HPLC), 96.5-103.5% (NT), 97%
form
powder
color
white to off-white
antibiotic activity spectrum
fungi, yeast
mode of action
cell membrane | interferes
Quality Level
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General description
Chemical structure: pyrimidine
Application
Tioconazole was used to study the synergistic mechanisms of antifungals on Candida albicans as well as significant drug-drug interactions in vivo.
Biochem/physiol Actions
Tioconazole is an antifungal medication of the imidazole class used to treat infections caused by fungus and yeast.It is more active than fluconazole or voriconazole against Candida glabrata mutant strains. It acts by membrane disruption and loss of intracellular ATP.
Packaging
10G
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Synergistic action of nikkomycin X/Z with azole antifungals on Candida albicans.
Slawomir Milewski, Fiorenzo Mignini, et. Al
Microbiology, 137, 2155-2161 (1991)
Wenjiang Zhang et al.
Drug metabolism and disposition: the biological fate of chemicals, 30(3), 314-318 (2002-02-21)
The interactions of a panel of antifungal agents with cytochromes P450 (P450s), as a means of predicting potential drug-drug interactions, have not yet been investigated. The objective of this study was to evaluate the specificity and selectivity of five antifungal
A J Carrillo-Muñoz et al.
Chemotherapy, 50(6), 308-313 (2004-12-21)
We have tested 250 strains belonging to 15 species of clinically important dermatophytes and Scopulariopsis against ten antifungal drugs using an agar diffusion method (NeoSensitabstrade mark, Rosco, Taastrup, Denmark). Some of the experimental factors were adapted to dermatophyte development, such
C Nolting et al.
Mycoses, 40 Suppl 1, 73-75 (1997-01-01)
We report on a 75 year old patient with a bronchial asthma treated at least for 15 years with low dose prednisolone. Under this treatment he developed a tinea follicularis and was demonstrated in our clinic with papulopustular skin lesions
A Defontaine et al.
Journal of medical microbiology, 48(7), 663-670 (1999-07-14)
A commercially available disk diffusion procedure was used in a large-scale study to evaluate the susceptibility of a wide range of Candida isolates to polyenes and azoles. With almost all isolates of C. glabrata resistant colonies were present within the
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