质量水平
方案
≥98.0%
98.0-102.0% (T)
SMILES字符串
OC(=O)c1ccnc(c1)C(O)=O
OC(=O)c1ccnc(c1)C(O)=O
InChI
1S/C7H5NO4/c9-6(10)4-1-2-8-5(3-4)7(11)12/h1-3H,(H,9,10)(H,11,12)
InChI key
MJIVRKPEXXHNJT-UHFFFAOYSA-N
应用
2,4-吡啶二羧酸是一种体外和细胞内抑制剂，也是组蛋白赖氨酸脱甲基酶的一种已知抑制剂。2,4-吡啶二甲酸已被用于一项研究中，以确定钌（II）配合物在体外对几种肿瘤细胞系具有抗转移作用，并且主要通过对细胞粘附、迁移和血管生成的影响来实现的。2,4-吡啶二甲酸已被用于开发一种检测方法，首次报道针对表观遗传学靶标的RapidFire质谱分析。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
John R G Sander et al.
Journal of pharmaceutical sciences, 99(9), 3676-3683 (2010-06-25)
We report on a co-crystal of acetaminophen (APAP) and 2,4-pyridinedicarboxylic acid (PDA). The co-crystal was discovered by screening using the solution-mediated phase transformation (SMPT) technique. Despite the bulk solids of each component being white in color, the new co-crystal phase
C K Derian et al.
The Journal of biological chemistry, 264(12), 6615-6618 (1989-04-25)
While a role has been ascribed to the gamma-carboxyglutamate (Gla) residues in vitamin K-dependent coagulation proteins and the enzyme catalyzing this posttranslational modification has been identified and partially characterized, both the functional significance of a second posttranslationally synthesized amino acid
H M Rowe et al.
Applied spectroscopy, 57(5), 532-537 (2003-12-09)
An adaptation of square-wave gated phase-modulation (GPM) fluorimetry allows for self-referenced intensity measurements without the complexity of dual excitation or dual emission wavelengths. This AC technique utilizes square-wave excitation, gated detection, a reference emitter, and a sensor molecule. The theory
Guo-liang Gu et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 71(1), 209-214 (2008-02-19)
Two novel ligands containing two pyridine-2,6-dicarboxylic acid conjugative units, 4-(2-(2,6-dicarbox-ypyridin-4-yl)vinyl)pyridine-2,6-dicarboxylic acid (L1) and 4-(4-(2-(2,6-dicarboxypyridin-4-yl)vinyl)styryl)pyridine-2,6-dicarboxylic acid (L2) and their complexes with Tb(III) have been synthesized and characterized by elemental analysis, IR spectra and NMR. The ligand synthetic route was optimized and
Michael Raghunath et al.
Biochemical and biophysical research communications, 378(4), 766-771 (2008-12-11)
The rapid vascularisation of biomaterials and engineered tissue after implantation is a current unmet need. To this end, we explored the pharmacological option of inducing neovascularisation using compounds that inhibit hypoxia-induced factor-1alpha prolyl hydroxylase. This stabilises hypoxia inducible factor-1alpha and
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