Quality Level
assay
≥98.0%, 98.0-102.0% (T)
InChI
1S/C7H5NO4/c9-6(10)4-1-2-8-5(3-4)7(11)12/h1-3H,(H,9,10)(H,11,12)
InChI key
MJIVRKPEXXHNJT-UHFFFAOYSA-N
Application
2,4-吡啶二羧酸是一种体外和细胞内抑制剂，也是组蛋白赖氨酸脱甲基酶的一种已知抑制剂。2,4-吡啶二甲酸已被用于一项研究中，以确定钌（II）配合物在体外对几种肿瘤细胞系具有抗转移作用，并且主要通过对细胞粘附、迁移和血管生成的影响来实现的。2,4-吡啶二甲酸已被用于开发一种检测方法，首次报道针对表观遗传学靶标的RapidFire质谱分析。
Still not finding the right product?
Explore all of our products under 2,4-吡啶二羧酸
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Line H Kristensen et al.
The FEBS journal, 279(11), 1905-1914 (2012-03-17)
Dynamic methylations and demethylations of histone lysine residues are important for gene regulation and are facilitated by histone methyltransferases and histone demethylases (HDMs). KDM5B/Jarid1B/PLU1 is an H3K4me3/me2-specific lysine demethylase belonging to the JmjC domain-containing family of histone demethylases (JHDMs). Several
G Tschank et al.
The Biochemical journal, 275 ( Pt 2), 469-476 (1991-04-15)
The biochemical and morphological consequences of procollagen prolyl 4-hydroxylase inhibition by pyridine-2,4-dicarboxylic acid (2,4-PDCA) and its diethyl ester (diethyl-2,4-PDC) were studied in chick-embryo calvaria, which predominantly synthesize type I collagen. Half-maximal inhibition of tissue hydroxyproline formation required 650 microM-2,4-PDCA, whereas
Sue E Hutchinson et al.
Journal of biomolecular screening, 17(1), 39-48 (2011-08-24)
A high-throughput RapidFire mass spectrometry assay is described for the JMJD2 family of Fe(2+), O(2), and α-ketoglutarate-dependent histone lysine demethylases. The assay employs a short amino acid peptide substrate, corresponding to the first 15 amino acid residues of histone H3
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 143618-500G | 04061832278599 |
| 143618-100G | 04061838734921 |
| 04473-5G | 04061838630681 |