04846
Phenyl β-D-thioglucopyranoside
≥98% (HPLC)
别名:
Phenyl β-D-thioglucoside, Phenyl 1-thio-β-D-glucopyranoside
方案
≥98% (HPLC)
表单
powder
旋光性
[α]/D +48.5±2.0°, c = 1 in ethanol
杂质
11.1-12.4% sulfur content
储存温度
−20°C
SMILES字符串
OC[C@H]1O[C@@H](Sc2ccccc2)[C@H](O)[C@@H](O)[C@@H]1O
InChI
1S/C12H16O5S/c13-6-8-9(14)10(15)11(16)12(17-8)18-7-4-2-1-3-5-7/h1-5,8-16H,6H2/t8-,9-,10+,11-,12+/m1/s1
InChI key
OVLYAISOYPJBLU-ZIQFBCGOSA-N
应用
Inhibition studies of a broad-specificity β-D-glucosidase
生化/生理作用
Phenyl β-D-thioglucopyranoside was shown to inhibit the activity of sodium-D-glucose cotransporter (SGLT) 1 and 2 by a competitive inhibition mechanism. Phenyl β-D-thioglucopyranoside had a stronger inhibitory effect on SGLT2 than 1.
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes.
Castaneda, F
International Journal of Clinical and Experimental Medicine, 4, 131-139 (2007)
I Pócsi et al.
The Biochemical journal, 256(1), 139-146 (1988-11-15)
A broad-specificity beta-D-glucosidase from pig kidney cortex was isolated and purified to homogeneity by a rapid purification procedure. The pI (5.14 +/- 0.05), Mr (59,000 +/- 2000) and specific activities with several p-nitrophenyl glycosides (galactopyranoside, glucopyranoside, arabinopyranoside, xylopyranoside) were comparable
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