06880
4-氨基联苯胺 二盐酸盐
BioReagent, suitable for fluorescence, ≥99.0% (TLC)
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线性分子式:
H2NC6H4C(=NH)NH2·2HCl
化学文摘社编号:
分子量:
208.09
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
219-692-2
MDL number:
Beilstein/REAXYS Number:
3692927
产品名称
4-氨基联苯胺 二盐酸盐, BioReagent, suitable for fluorescence, ≥99.0% (TLC)
SMILES string
Cl[H].Cl[H].NC(=N)c1ccc(N)cc1
Cl[H].Cl[H].NC(=N)c1ccc(N)cc1
InChI key
GHEHNICLPWTXJC-UHFFFAOYSA-N
InChI
1S/C7H9N3.2ClH/c8-6-3-1-5(2-4-6)7(9)10;;/h1-4H,8H2,(H3,9,10);2*1H
product line
BioReagent
assay
≥99.0% (TLC)
form
powder or crystals
mp
>300 °C (lit.)
fluorescence
λex >300 nm in H2O
suitability
suitable for fluorescence
storage temp.
2-8°C
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Analysis Note
Emmax: none
Other Notes
Competitive inhibitor of serine proteases; As a fluorescent probe for the active site of serine proteases
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
S A Evans et al.
The Journal of biological chemistry, 257(6), 3014-3017 (1982-03-25)
p-Aminobenzamidine is weakly fluorescent in neutral aqueous buffer, with excitation and emission maxima at 293 and 376 nm, respectively. Binding to trypsin results in a blue shift of the emission peak to 362 nm, and 50-fold fluorescence enhancement, while binding
STUDIES ON THE ACTIVE CENTER OF TRYPSIN. THE BINDING OF AMIDINES AND GUANIDINES AS MODELS OF THE SUBSTRATE SIDE CHAIN.
M MARES-GUIA et al.
The Journal of biological chemistry, 240, 1579-1585 (1965-04-01)
Comparative studies on the inhibition of trypsin, plasmin, and thrombin by derivatives of benzylamine and benzamidine.
F Markwardt et al.
European journal of biochemistry, 6(4), 502-506 (1968-12-05)
Nathan J Alves et al.
Biochemical and biophysical research communications, 457(3), 358-362 (2015-01-13)
The potent fibrinolytic enzyme, plasmin has numerous clinical applications for recannulizing vessels obstructed by thrombus. Despite its diminutive size, 91 kDa, success in the recombinant expression of this serine protease has been limited. For this reason, a truncated non-glycosylated plasmin
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