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Merck
CN

08520

Quin-2

suitable for fluorescence, ≥95% (HPLC)

别名:

2-[(2-Amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-N,N,N′,N′-tetraacetic acid tetrapotassium salt, 2-{[2-Bis-(carboxymethyl)amino-5-methylphenoxy]-methyl}-6-methoxy-8-bis-(carboxymethyl)aminoquinoline tetrapotassium salt, Glycine,N-[2-[[8-[bis(carboxymethyl)amino]-6-methoxy-2-quinolinyl]methoxy]-4-methylphenyl]-N-(carboxymethyl)-,potassium salt (1:4), Quin 2, Tetrapotassium Salt, tetrapotassium 2-[[2-[[2-[bis(2-oxido-2-oxoethyl)amino]-5-methylphenoxy]methyl]-6-methoxyquinolin-8-yl]-(2-oxido-2-oxoethyl)amino]acetate

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关于此项目

经验公式（希尔记法）:
C26H23K4N3O10
化学文摘社编号:
73630-23-6
分子量:
693.87
Beilstein:
5374262
MDL编号:
MFCD00065487
UNSPSC代码:
12352106
PubChem化学物质编号:
329748596
NACRES:
NA.32

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方案

≥95% (HPLC)

溶解性

H2O: 10 mg/mL

荧光

λex 332 nm; λem 493 nm in 0.1 M Tris pH 8.0, 10 mM Ca2+

适用性

suitable for fluorescence

储存温度

2-8°C

SMILES字符串

[K+].[K+].[K+].[K+].COc1cc(N(CC([O-])=O)CC([O-])=O)c2nc(COc3cc(C)ccc3N(CC([O-])=O)CC([O-])=O)ccc2c1
[K+].[K+].[K+].[K+].COc1cc(N(CC([O-])=O)CC([O-])=O)c2nc(COc3cc(C)ccc3N(CC([O-])=O)CC([O-])=O)ccc2c1

InChI

1S/C26H27N3O10.4K/c1-15-3-6-19(28(10-22(30)31)11-23(32)33)21(7-15)39-14-17-5-4-16-8-18(38-2)9-20(26(16)27-17)29(12-24(34)35)13-25(36)37;;;;/h3-9H,10-14H2,1-2H3,(H,30,31)(H,32,33)(H,34,35)(H,36,37);;;;/q;4*+1/p-4

InChI key

XAGUNWDMROKIFJ-UHFFFAOYSA-J

应用

Quin-2 has been demonstrated to be an indicator of Zn2+-protein complexes .

其他说明

A fluorescent highly selective Ca++ indicator exhibiting fast uptake and release of Ca++; Calibration substance in the measurement of cytoplasmic free calcium

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN6131
BCCL1610
BCCG4756
BCCJ3388
BCCF4573

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Deepani D Fernando et al.
PLoS neglected tropical diseases, 15(1), e0008997-e0008997 (2021-01-07)
Scabies, a highly contagious skin disease affecting more than 200 million people worldwide at any time, is caused by the parasitic mite Sarcoptes scabiei. In the absence of molecular markers, diagnosis requires experience making surveillance and control challenging. Superficial microthrombi
R Y Tsien
Biochemistry, 19(11), 2396-2404 (1980-05-27)
A new family of high-affinity buffers and optical indicators for Ca2+ is rationally designed and synthesized. The parent compound is 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA), a relative of the well-known chelator EGTA [ethylene glycol bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid] in which methylene links between
R Y Tsien et al.
The Journal of cell biology, 94(2), 325-334 (1982-08-01)
A new, fluorescent, highly selective Ca2+ indicator , "quin2", has been trapped inside intact mouse and pig lymphocytes, to measure and manipulate cytoplasmic free Ca2+ concentrations, [Ca2+]i. Quin2 is a tetracarboxylic acid which binds Ca2+ with 1:1 stoichiometry and an
Shiwanthi L Ranasinghe et al.
Parasitology, 142(14), 1663-1672 (2015-10-16)
Little is known about the molecular mechanisms whereby the human blood fluke Schistosoma japonicum is able to survive in the host venous blood system. Protease inhibitors are likely released by the parasite enabling it to avoid attack by host proteolytic

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