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Merck
CN

08658

8-氨基萘-1,3,6-三磺酸 二钠盐

BioReagent, suitable for fluorescence, ≥90% (CE)

别名:

8-氨基-1,3,6-萘三磺酸二钠, ANTS

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关于此项目

经验公式（希尔记法）:
C10H7NNa2O9S3
化学文摘社编号:
5398-34-5
分子量:
427.34
NACRES:
NA.32
PubChem Substance ID:
329748624
UNSPSC Code:
12352106
EC Number:
226-431-6
MDL number:
MFCD00070572
Beilstein/REAXYS Number:
3854839

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产品名称

8-氨基萘-1,3,6-三磺酸 二钠盐, BioReagent, suitable for fluorescence, ≥90% (CE)

SMILES string

[Na+].[Na+].Nc1cc(cc2cc(cc(c12)S([O-])(=O)=O)S([O-])(=O)=O)S(O)(=O)=O
[Na+].[Na+].Nc1cc(cc2cc(cc(c12)S([O-])(=O)=O)S([O-])(=O)=O)S(O)(=O)=O

InChI key

KHJANRFXWPPWEL-UHFFFAOYSA-L

InChI

1S/C10H9NO9S3.2Na/c11-8-3-6(21(12,13)14)1-5-2-7(22(15,16)17)4-9(10(5)8)23(18,19)20;;/h1-4H,11H2,(H,12,13,14)(H,15,16,17)(H,18,19,20);;/q;2*+1/p-2

product line

BioReagent

assay

≥90% (CE)

impurities

~8% water

solubility

15% acetic acid: soluble
H2O: soluble

fluorescence

λex 356 nm; λem 512 nm in 0.1 M phosphate pH 7.0

suitability

suitable for fluorescence

Quality Level

200

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Application

用于寡糖测序的糖类和糖蛋白荧光标记。
糖和糖蛋白的荧光标记，用于寡糖测序以及膜通透性和脂质体裂解的研究。
该分子试剂是一种聚阴离子染料，通常会与阳离子猝灭剂DPX（X1525）结合用于膜融合或通透性测定，包括补体介导的免疫裂解。ANTS的荧光已证实可被铊和铯离子有效淬灭。可用作神经元示踪剂。ANTS在水中具有相对较高的斯托克斯位移，这足以将其发射的光与生物样品的大多数自发荧光区分开。 D2O可将ANTS的荧光量子产率提高四倍，而这已被证明可用于测定红细胞鬼影和肾脏收集管中的透水性。碳水化合物的还原末端可与ANTS分子的伯氨基发生反应形成席夫碱，其随后可通过氰基硼氢化钠被还原为仲胺。该还原性胺化反应是酸催化的，因此反应溶液的pH值可通过ANTS改变碳水化合物的动力学和衍生化程度。需要特别注意的是，该反应能够在中性pH下进行，而这对于寡糖中对酸水解敏感的唾液酸键的完整性是有利的。用ANTS对碳水化合物进行这样的标记使得通过毛细管电泳对复杂的混合物进行分离成为可能。

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCK3972
BCBR8265V
BCBL1311V

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Philipp A M Schmidpeter et al.
Nature communications, 11(1), 6401-6401 (2020-12-18)
SthK, a cyclic nucleotide-modulated ion channel from Spirochaeta thermophila, activates slowly upon cAMP increase. This is reminiscent of the slow, cAMP-induced activation reported for the hyperpolarization-activated and cyclic nucleotide-gated channel HCN2 in the family of so-called pacemaker channels. Here, we
Shee-Mei Lok et al.
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Dengue virus infects approximately 100 million people annually, but there is no available therapeutic treatment. The mimetic peptide, DN59, consists of residues corresponding to the membrane interacting, amphipathic stem region of the dengue virus envelope (E) glycoprotein. This peptide is
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A broad spectrum of beneficial effects has been ascribed to creatine (Cr), phosphocreatine (PCr) and their cyclic analogues cyclo-(cCr) and phospho-cyclocreatine (PcCr). Cr is widely used as nutritional supplement in sports and increasingly also as adjuvant treatment for pathologies such
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Deep brain stimulation (DBS) therapy requires extensive patient-specific planning prior to implantation to achieve optimal clinical outcomes. Collective analysis of patient's brain images is promising in order to provide more systematic planning assistance. In this paper the design of a
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Ultra-high field MRI can functionally image the cerebral cortex of human subjects at the submillimeter scale of cortical columns and laminae. Here, we investigate both in concert, by imaging ocular dominance columns (ODCs) in primary visual cortex (V1) across different
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