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Merck
CN

10385

Angiotensin III trifluoroacetate salt hydrate

≥98% (HPCE)

别名:

Des-Asp-1-Angiotensin II trifluoroacetate salt hydrate

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关于此项目

经验公式（希尔记法）:
C46H66N12O9 · xC2HF3O2 · yH2O
化学文摘社编号:
12687-51-3
分子量:
931.09 (anhydrous free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
57646800
MDL number:
MFCD20264812
Beilstein/REAXYS Number:
8385695

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产品名称

Angiotensin III trifluoroacetate salt hydrate, ≥98% (HPCE)

InChI

1S/C46H66N12O9.C2HF3O2.H2O/c1-5-27(4)38(57-40(61)33(21-29-15-17-31(59)18-16-29)53-42(63)37(26(2)3)56-39(60)32(47)13-9-19-51-46(48)49)43(64)54-34(23-30-24-50-25-52-30)44(65)58-20-10-14-36(58)41(62)55-35(45(66)67)22-28-11-7-6-8-12-28;3-2(4,5)1(6)7;/h6-8,11-12,15-18,24-27,32-38,59H,5,9-10,13-14,19-23,47H2,1-4H3,(H,50,52)(H,53,63)(H,54,64)(H,55,62)(H,56,60)(H,57,61)(H,66,67)(H4,48,49,51);(H,6,7);1H2/t27-,32-,33-,34-,35-,36-,37-,38-;;/m0../s1

SMILES string

O.OC(=O)C(F)(F)F.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(O)=O

InChI key

JEOAJMGVSAMVML-UFPGTABSSA-N

assay

≥98% (HPCE)

solubility

H2O: 1.0 mg/mL, clear, colorless

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Angiotensin III is an AT1 and AT2 agonist, with higher sensitivity for the AT2 receptor. Ang III has been shown to be a main effector peptide in RAS-controlled vasopresin release and a stimulator for aldosterone release.

Features and Benefits

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

Angiotensin III (Ang III) is a 7-AA bioactive peptide that is formed from the degradation of the Angiotensin II peptide by aminopeptidase A; both are derivatives of angiotensinogen and are components of the renin-angiotensin system (RAS).
Arg-Val-Tyr-Ile-His-Pro-Phe-OH.3CH3COOH.4H2O

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCM9038
BCCK4410
BCCK2388
BCCG8894
BCCG0845

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Hong Xia Wang et al.
Journal of cardiovascular pharmacology and therapeutics, 15(4), 393-402 (2010-09-24)
This study compared angiotensin II (Ang II) and angiotensin III (Ang III) for their effects on rat neonatal cardiomyocytes and cardiac fibroblasts in vitro and discussed the possible role of Ang III in the pathogenesis of cardiac remodeling. To do
Sadia Rabbani et al.
Analytical chemistry, 83(10), 3793-3800 (2011-04-06)
Time-of-flight secondary ion mass spectrometry (TOF-SIMS) is an established technique for the characterization of solid sample surfaces. The introduction of polyatomic ion beams, such as C(60), has provided the associated ability to perform molecular depth-profiling and 3D molecular imaging. However
Nadja Grobe et al.
American journal of physiology. Endocrinology and metabolism, 302(8), E1016-E1024 (2012-02-10)
To better understand the tissue distribution and activity of enzymes involved in angiotensin II (Ang II) processing, we developed a novel molecular imaging method using matrix-assisted laser desorption ionization-time-of-flight (MALDI-TOF) mass spectrometry. Mouse kidney sections (12 μm) were incubated with
Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension
Wright, J.W., et al.
International Journal of Hypertension, doi: 10-doi: 10 (2011)
Bing S Huang et al.
Cardiovascular research, 97(3), 424-431 (2012-12-22)
In rats post-myocardial infarction (MI), activation of angiotensinergic pathways in the brain contributes to sympathetic hyperactivity and progressive left ventricle (LV) dysfunction. The present study examined whether angiotensin III (Ang III) is one of the main effector peptides of the
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