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Merck
CN

10385

Angiotensin III trifluoroacetate salt hydrate

≥98% (HPCE)

别名:

Des-Asp-1-Angiotensin II trifluoroacetate salt hydrate

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关于此项目

经验公式（希尔记法）:
C46H66N12O9 · xC2HF3O2 · yH2O
化学文摘社编号:
12687-51-3
分子量:
931.09 (anhydrous free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
57646800
MDL number:
MFCD20264812
Beilstein/REAXYS Number:
8385695

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InChI

1S/C46H66N12O9.C2HF3O2.H2O/c1-5-27(4)38(57-40(61)33(21-29-15-17-31(59)18-16-29)53-42(63)37(26(2)3)56-39(60)32(47)13-9-19-51-46(48)49)43(64)54-34(23-30-24-50-25-52-30)44(65)58-20-10-14-36(58)41(62)55-35(45(66)67)22-28-11-7-6-8-12-28;3-2(4,5)1(6)7;/h6-8,11-12,15-18,24-27,32-38,59H,5,9-10,13-14,19-23,47H2,1-4H3,(H,50,52)(H,53,63)(H,54,64)(H,55,62)(H,56,60)(H,57,61)(H,66,67)(H4,48,49,51);(H,6,7);1H2/t27-,32-,33-,34-,35-,36-,37-,38-;;/m0../s1

SMILES string

O.OC(=O)C(F)(F)F.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(O)=O

InChI key

JEOAJMGVSAMVML-UFPGTABSSA-N

assay

≥98% (HPCE)

solubility

H2O: 1.0 mg/mL, clear, colorless

storage temp.

−20°C

Quality Level

100

General description

Angiotensin III (Ang III) is a 7-AA bioactive peptide that is formed from the degradation of the Angiotensin II peptide by aminopeptidase A; both are derivatives of angiotensinogen and are components of the renin-angiotensin system (RAS).
Arg-Val-Tyr-Ile-His-Pro-Phe-OH.3CH3COOH.4H2O

Biochem/physiol Actions

Angiotensin III is an AT1 and AT2 agonist, with higher sensitivity for the AT2 receptor. Ang III has been shown to be a main effector peptide in RAS-controlled vasopresin release and a stimulator for aldosterone release.

Features and Benefits

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCP2235
BCCM9038
BCCK4410
BCCK2388
BCCG8894

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Kamila Domińska et al.
Endokrynologia Polska, 60(5), 363-369 (2009-11-04)
The results of many studies have reported that peptides from the angiotensin family are involved in the regulation of cell growth, proliferation, cell migration, apoptosis, inflammation, differentiation, and angiogenesis, which suggests that they might play an important role in carcinogenesis.
Kenji Oki et al.
Endocrinology, 154(1), 214-221 (2012-12-12)
Aldosterone is synthesized in the zona glomerulosa of the adrenal cortex under primary regulation by the renin-angiotensin system. Angiotensin II (A-II) acts through the angiotensin types 1 and 2 receptors (AT1R and AT2R). A-II is metabolized in different tissues by
Rui Yang et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 34(6), 674-683 (2011-03-18)
Angiotensin (Ang) II, the main effector peptide of the renin-Ang system, increases arterial blood pressure through Ang II type 1A (AT(1a)) receptor-dependent arterial vasoconstriction and by decreasing renal salt and water excretion through extrarenal and intrarenal mechanisms. AT(2) receptors are
[Angiotensin I, angiotensin II, angiotensin III].
Chigusa Nakamura et al.
Nihon rinsho. Japanese journal of clinical medicine, 68 Suppl 7, 608-610 (2010-10-22)
Maria del Pilar Carrera et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 31(6), 583-588 (2010-07-24)
Angiotensin II in particular and/or the local renin-angiotensin system in general could have an important role in epithelial tissue growth and modelling; therefore, it is possible that it may be involved in breast cancer. In this sense, previous works of
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