biological source
mouse
conjugate
unconjugated
antibody form
diluted ascites fluid
antibody product type
primary antibodies
clone
C8/144B, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (108M-94)
vial of 0.5 mL concentrate (108M-95)
bottle of 1.0 mL predilute (108M-97)
vial of 1.0 mL concentrate (108M-96)
bottle of 7.0 mL predilute (108M-98)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
isotype
IgG1κ
control
tonsil
shipped in
wet ice
storage temp.
2-8°C
visualization
membranous
Gene Information
human ... CD8A(925)
Other Notes
CD8 Positive Control Slides, Product No. 108S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
Analysis Note
 IVD |  IVD |  IVD |  RUO |
General description
Anti-CD8 is a T cell marker for the detection of cytotoxic/suppresser cells of blood lymphocytes. CD8 is also detected on NK cells, most thymocytes, a subpopulation of null cells and bone marrow cells. This antibody, along with other markers, can be used to distinguish between reactive and neoplastic T-cells.
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法规信息
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M L Rossi et al.
Journal of clinical pathology, 41(3), 314-319 (1988-03-01)
Twenty four meningiomas (17 benign and seven "atypical" were reacted with a panel of monoclonal antibodies to macrophages, lymphocytes, and HLA DR antigens. All the tumours contained macrophages but these cells were more numerous in the atypical meningiomas. Lymphocytes, almost
Immunohistological analysis of human lymphoma: correlation of histological and immunological categories.
H Stein et al.
Advances in cancer research, 42, 67-147 (1984-01-01)
F Phan-Dinh-Tuy et al.
Molecular immunology, 19(12), 1649-1654 (1982-12-01)
Three human lymphocyte differentiation antigens, specific of the entire T-cell population, of the helper/inducer T-cell subset, and of the cytotoxic/suppressor T-cell subset have been identified, using mouse monoclonal antibodies obtained from Dr. P. Kung. Various T-cell populations were radio-labelled, the
J D Nuckols et al.
Journal of cutaneous pathology, 26(4), 169-175 (1999-05-21)
Differentiation between mycosis fungoides (MF) and cutaneous inflammatory processes can usually be made on clinical and histologic grounds. In difficult cases, immunohistochemical studies can be helpful since MF infiltrates usually contain a predominance of CD4+ lymphocytes, while most inflammatory lesions
D Y Mason et al.
Journal of clinical pathology, 45(12), 1084-1088 (1992-12-01)
To evaluate whether cytotoxic/suppressor T cells can be detected in paraffin wax embedded human tissue samples using antibodies to a synthetic CD8 peptide sequence. Polyclonal and monoclonal antibodies were raised against a 13 amino acid peptide sequence from the cytoplasmic
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