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Merck
CN

111R-1

CD11c (EP157) Rabbit Monoclonal Primary Antibody

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关于此项目

UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
EP157, monoclonal
Application:
IHC (p)
Citations:
3

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biological source

rabbit

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP157, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (111R-14), vial of 0.1 mL concentrate Research Use Only (111R-14-RUO), vial of 0.5 mL concentrate (111R-15), vial of 1.0 mL concentrate (111R-16), vial of 1.0 mL concentrate Research Use Only (111R-16-RUO), vial of 1.0 mL pre-dilute Research Use Only (111R-17-RUO), vial of 1.0 mL pre-dilute ready-to-use (111R-17), vial of 7.0 mL pre-dilute ready-to-use (111R-18), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (111R-18-RUO)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)

isotype

IgG

control

hairy cell leukemia, spleen, tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... ITGAX(3687)

相关类别

General description

CD11c is an adhesion receptor of the leukocyte function-associated family of molecules. This cell surface antigen is normally expressed on granulocytes, monocytes, natural killer cells, macrophages, and small populations of T- and B-lymphocytes. Anti-CD11c detects a formalin-resistant epitope of CD11c expressed in hairy cell leukemia (HCL). HCL is a distinctive yet uncommon chronic B-cell lymphoproliferative disorder, predominantly involving the bone marrow and spleen. Besides being consistently expressed in HCL, CD11c is rarely detected in lymphomas; such as small lymphocytic lymphoma (SLL), and nodal and extranodal marginal zone lymphoma (MZL).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note


IVD
IVD
IVD
RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000125711
0000119026
0000117464
0000108256
0000108255

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G Marotta et al.
Leukemia & lymphoma, 37(1-2), 145-149 (2000-03-18)
This study analyzed the expression of the beta2 integrin CD11c in 155 patients with well-characterized B-cell chronic lymphoproliferative disorders: 106 B-cell chronic lymphocytic leukemias (B-CLL), 21 hairy cell leukemias (HCL), 9 B-cell prolymphocytic leukemias (PLL) and 19 low grade non-Hodgkin's
Gail Jones et al.
British journal of haematology, 156(2), 186-195 (2011-11-25)
The British Committee for Standards in Haematology first produced guidelines for the diagnosis and management of hairy cell leukaemia and hairy cell leukaemia variant in 2000. This revision updates those guidelines and covers the areas of diagnosis, treatment and assessment
Korinna Johrens et al.
Pathobiology : journal of immunopathology, molecular and cellular biology, 75(4), 252-256 (2008-06-27)
The diagnosis of hairy cell leukemia (HCL) and its distinction from other B-cell lymphomas can be difficult in formalin-fixed tissue. This is because the histology is not always classical, and despite having a characteristic phenotype, there are few relevant monoclonal

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