14370
胆红素
purum, ≥95.0% (UV)
别名:
Bile pigment, Hemetoidin
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关于此项目
经验公式（希尔记法）:
C33H36N4O6
化学文摘社编号:
分子量:
584.66
UNSPSC Code:
12352202
NACRES:
NA.25
PubChem Substance ID:
EC Number:
211-239-7
Beilstein/REAXYS Number:
74376
MDL number:
产品名称
胆红素, purum, ≥95.0% (UV)
InChI
1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-
InChI key
BPYKTIZUTYGOLE-IFADSCNNSA-N
SMILES string
CC1=C(C=C)\C(NC1=O)=C\c2[nH]c(Cc3[nH]c(\C=C4/NC(=O)C(C=C)=C4C)c(C)c3CCC(O)=O)c(CCC(O)=O)c2C
grade
purum
assay
≥95.0% (UV)
form
powder
ign. residue
≤0.5%
Quality Level
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Analysis Note
λmax。∼453 nm，摩尔吸光度>56100（溶剂为氯仿）
Application
使用胆红素作为肌红蛋白、肌酸激酶-MB（CK-MB）和肌钙蛋白-I 体外干扰和稳定性测试的干扰物质。此外，还被用作干扰剂，以测试肝素红试剂盒检测各种肝素的有效性。
Biochem/physiol Actions
胆红素是一种活性氧化 DNA 裂解剂，也是一种有效的抗氧化剂，即羟基猝灭剂。这种胆色素同时具有抗氧化性和毒害性。它是血管平滑肌细胞增殖（VSMC）的天然抑制剂。当用于肺/血管疾病的治疗药物时，它显示出抗炎和抗增殖特性。血清胆红素浓度略高于正常水平表示心脏疾病发病率较低。它是心脏移植和 T 细胞介导免疫功能紊乱的治疗药物。
超过99%的胆红素与白蛋白结合运输。胆红素水平异常高会导致严重的神经损伤，但轻度升高与抗氧化应激反应有关。
General description
胆红素是血红素分解代谢的最终产物，通过酶胆绿素还原酶的作用还原代谢前体胆绿素而产生。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Stefan W Ryter et al.
American journal of respiratory cell and molecular biology, 36(2), 175-182 (2006-09-19)
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Yen-Wen Wu et al.
Acta Cardiologica Sinica, 36(6), 649-659 (2020-11-26)
The rapid diagnosis of acute myocardial infarction (AMI) is a clinical and operational priority in emergency departments. Serial serum levels of cardiac biomarkers play a crucial role in the evaluation of patients presenting with acute chest pain, so that an
U Warttinger et al.
Analytical and bioanalytical chemistry, 408(28), 8241-8251 (2016-10-22)
Heparins are widely used anticoagulant drugs. The current monitoring practice for heparin in plasma, such as the chromogenic anti-factor Xa assay, relies on heparin-triggered activation of antithrombin, an inhibitor of coagulation proteases. Such assays are not applicable to the detection
Robert Ollinger et al.
Cell cycle (Georgetown, Tex.), 6(1), 39-43 (2007-01-25)
We have recently shown that the natural bile pigment bilirubin has antiproliferative effects on vascular smooth muscle cells (VSMCs). Bilirubin is the end product of heme catabolism mediated by heme oxygenases and has for decades been considered a toxic waste
Robert Ollinger et al.
Circulation, 112(7), 1030-1039 (2005-08-10)
Bilirubin, a natural product of heme catabolism by heme oxygenases, was considered a toxic waste product until 1987, when its antioxidant potential was recognized. On the basis of observations that oxidative stress is a potent trigger in vascular proliferative responses
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