14408
N-(+)-Biotinyl-4-aminobenzoic acid
≥98.0% (HPLC)
别名:
B-PABA
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关于此项目
经验公式（希尔记法）:
C17H21N3O4S
化学文摘社编号:
分子量:
363.43
NACRES:
NA.79
PubChem Substance ID:
eCl@ss:
34058011
UNSPSC Code:
12352106
MDL number:
Beilstein/REAXYS Number:
50100
产品名称
N-(+)-Biotinyl-4-aminobenzoic acid, ≥98.0% (HPLC)
InChI
1S/C17H21N3O4S/c21-14(18-11-7-5-10(6-8-11)16(22)23)4-2-1-3-13-15-12(9-25-13)19-17(24)20-15/h5-8,12-13,15H,1-4,9H2,(H,18,21)(H,22,23)(H2,19,20,24)/t12-,13-,15-/m0/s1
SMILES string
[H][C@]12CS[C@@H](CCCCC(=O)Nc3ccc(cc3)C(O)=O)[C@@]1([H])NC(=O)N2
InChI key
PVMDAMXGKHIMSQ-YDHLFZDLSA-N
assay
≥98.0% (HPLC)
form
powder
optical activity
[α]20/D +55±3°, c = 0.5% in 0.1 M NaOH
color
white to light yellow
mp
295-297 °C
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Biotinyl-4-aminobenzoic acid (B-PABA) is used as a substrate in biotinidase assays.
Other Notes
Enzyme substrate used in the assay of biotinidase
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
D V Craft et al.
Biochemistry, 24(10), 2471-2476 (1985-05-07)
Biotinidase catalyzes the hydrolysis of N epsilon-biotinyllysine (biocytin) to form biotin and free lysine. The enzyme has been purified 4800-fold from outdated human plasma and was determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis to have a molecular weight of (76
Determination of biotinidase activity by liquid chromatography with fluorimetric detection.
K Hayakawa et al.
Journal of chromatography, 383(1), 148-152 (1986-11-28)
Keyna A Kobza et al.
The Journal of nutritional biochemistry, 19(12), 826-832 (2008-05-16)
Posttranslational modification of histones by biotinylation can be catalyzed by both biotinidase (BTD) and holocarboxylase synthetase. Biotinylation of histones is an important epigenetic mechanism to regulate gene expression, DNA repair, and chromatin remodeling. The role of BTD in histone biotinylation
D T Forman et al.
Annals of clinical and laboratory science, 22(3), 144-154 (1992-05-11)
Children with juvenile-onset multiple carboxylase deficiency lack biotinidase activity (biotinamide amidohydrolase, EC 3.5.1.12) in the liver and other tissues. Hence, little free biotin is metabolically available, resulting in seizures, acidosis, and serious neurological damage. As the absence of hepatic biotinidase
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