14408
N-(+)-Biotinyl-4-aminobenzoic acid
≥98.0% (HPLC)
别名:
B-PABA
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关于此项目
经验公式（希尔记法）:
C17H21N3O4S
化学文摘社编号:
分子量:
363.43
Beilstein:
50100
MDL编号:
UNSPSC代码:
12352106
eCl@ss:
34058011
PubChem化学物质编号:
NACRES:
NA.79
质量水平
方案
≥98.0% (HPLC)
表单
powder
旋光性
[α]20/D +55±3°, c = 0.5% in 0.1 M NaOH
颜色
white to light yellow
mp
295-297 °C
储存温度
2-8°C
SMILES字符串
[H][C@]12CS[C@@H](CCCCC(=O)Nc3ccc(cc3)C(O)=O)[C@@]1([H])NC(=O)N2
InChI
1S/C17H21N3O4S/c21-14(18-11-7-5-10(6-8-11)16(22)23)4-2-1-3-13-15-12(9-25-13)19-17(24)20-15/h5-8,12-13,15H,1-4,9H2,(H,18,21)(H,22,23)(H2,19,20,24)/t12-,13-,15-/m0/s1
InChI key
PVMDAMXGKHIMSQ-YDHLFZDLSA-N
生化/生理作用
Biotinyl-4-aminobenzoic acid (B-PABA) is used as a substrate in biotinidase assays.
其他说明
Enzyme substrate used in the assay of biotinidase
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
D V Craft et al.
Biochemistry, 24(10), 2471-2476 (1985-05-07)
Biotinidase catalyzes the hydrolysis of N epsilon-biotinyllysine (biocytin) to form biotin and free lysine. The enzyme has been purified 4800-fold from outdated human plasma and was determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis to have a molecular weight of (76
Keyna A Kobza et al.
The Journal of nutritional biochemistry, 19(12), 826-832 (2008-05-16)
Posttranslational modification of histones by biotinylation can be catalyzed by both biotinidase (BTD) and holocarboxylase synthetase. Biotinylation of histones is an important epigenetic mechanism to regulate gene expression, DNA repair, and chromatin remodeling. The role of BTD in histone biotinylation
Determination of biotinidase activity by liquid chromatography with fluorimetric detection.
K Hayakawa et al.
Journal of chromatography, 383(1), 148-152 (1986-11-28)
D T Forman et al.
Annals of clinical and laboratory science, 22(3), 144-154 (1992-05-11)
Children with juvenile-onset multiple carboxylase deficiency lack biotinidase activity (biotinamide amidohydrolase, EC 3.5.1.12) in the liver and other tissues. Hence, little free biotin is metabolically available, resulting in seizures, acidosis, and serious neurological damage. As the absence of hepatic biotinidase
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