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Merck
CN

14513

1,2-双(2-氨基苯氧基)乙烷-N,N,N′,N′-四乙酸 四钠盐

≥95% (HPLC)

别名:

1,2-Bis (2-aminophenoxy) ethane-N,N,N′,N′-tetraacetic acid tetrasodium salt, BAPTA-Na4, Tetrasodium 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetate

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关于此项目

经验公式（希尔记法）:
C22H20N2Na4O10
化学文摘社编号:
126824-24-6
分子量:
564.36
UNSPSC Code:
12352106
NACRES:
NA.32
PubChem Substance ID:
57647167
MDL number:
MFCD00067691
Beilstein/REAXYS Number:
8818619
Assay:
≥95% (HPLC)
Form:
powder

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产品名称

1,2-双(2-氨基苯氧基)乙烷-N,N,N′,N′-四乙酸 四钠盐, ≥95% (HPLC)

InChI

1S/C22H24N2O10.4Na/c25-19(26)11-23(12-20(27)28)15-5-1-3-7-17(15)33-9-10-34-18-8-4-2-6-16(18)24(13-21(29)30)14-22(31)32;;;;/h1-8H,9-14H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32);;;;/q;4*+1/p-4

SMILES string

[Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)c1ccccc1OCCOc2ccccc2N(CC([O-])=O)CC([O-])=O

InChI key

ZWSMLJACYSGFKD-UHFFFAOYSA-J

assay

≥95% (HPLC)

form

powder

impurities

≤12.5% water

solubility

H2O: 10 mg/mL, clear, faintly yellow

fluorescence

λex 254 nm; λem 363 nm in H2O
λex 274 nm; λem 363 nm (with calcium)

storage temp.

−20°C

Quality Level

200

Application

BAPTA-Na4 is a fluorescent compound utilized to determine free Ca2+ by performing fluorescence emission scans at an excitation wavelength of 299 nm and measuring the emission wavelength at 360 nm .
suitable as Ca2+-indicator (fluorescence suppressed by Ca2+)

Other Notes

Chelator with a greater selectivity for calcium compared with magnesium (spectrophotometric monitoring):

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
439238/1
417361/1
410217/1
071082/1
053864/1

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R Y Tsien
Biochemistry, 19(11), 2396-2404 (1980-05-27)
A new family of high-affinity buffers and optical indicators for Ca2+ is rationally designed and synthesized. The parent compound is 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA), a relative of the well-known chelator EGTA [ethylene glycol bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid] in which methylene links between
G Brent Dawe et al.
Neuron, 102(5), 976-992 (2019-05-06)
Neurotransmitter-gated ion channels are allosteric proteins that switch on and off in response to agonist binding. Most studies have focused on the agonist-bound, activated channel while assigning a lesser role to the apo or resting state. Here, we show that nanoscale

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