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Merck
CN

15205

杀稻瘟素S 盐酸盐

别名:

杀稻瘟菌素S

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关于此项目

经验公式(希尔记法):
C17H26N8O5 · HCl
化学文摘社编号:
分子量:
458.90
NACRES:
NA.76
PubChem Substance ID:
UNSPSC Code:
51102829
MDL number:
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form

powder

Quality Level

color

white to off-white

solubility

water: soluble, clear, colorless to faintly yellow

antibiotic activity spectrum

fungi

application(s)

agriculture
environmental

mode of action

protein synthesis | interferes

shipped in

dry ice

storage temp.

−20°C

SMILES string

Cl[H].CN(CC[C@@H](N)CC(=O)N[C@H]1C=C[C@@H](O[C@@H]1C(O)=O)N2C=CC(N)=NC2=O)C(N)=N

InChI

1S/C17H26N8O5.ClH/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29;/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29);1H/t9-,10+,13-,14+;/m1./s1

InChI key

YQXYQOXRCNEATG-ZAYJLJTISA-N

General description

化学结构:核苷
杀稻瘟素S属于抗生素的氨酰基核苷类。它抑制细菌和真核生物中的蛋白质合成。它还具有杀真菌特性,可预防稻瘟病。

Application

杀稻瘟菌素 S 用作含有抗性基因 bls、bsrBSD 的转化细胞的选择剂。 杀稻瘟菌素 S 已用于选择具有 TLR-2 构建体的 HEK293-T 细胞和 HEK-D5 细胞。 也用于研究肽键形成水平上的蛋白质合成。

Biochem/physiol Actions

杀稻瘟素S抑制释放因子诱导的肽基tRNA水解。它增强了tRNA与核糖体大亚基的结合,并在一定程度上抑制了肽键的形成。

Packaging

无底玻璃瓶。内含物装在锥底内插管中。

Other Notes

保存于密闭容器内,置于干燥通风处。置于干燥处保存。储存类别(TRGS 510):不可燃,急性毒性类别 1 和 2 /剧毒有害物质

pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 1 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

涉药品监管产品

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Egor Svidritskiy et al.
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全球贸易项目编号

货号GTIN
15205-100MG04061835541003
15205-25MG04061838740151

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