SMILES string
O2C(C2)C.O1CC1
InChI
1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
InChI key
RVGRUAULSDPKGF-UHFFFAOYSA-N
form
solid
mol wt
~7680-9510 g/mol
composition
oxyethylene, 79.9-83.7%
impurities
≤0.25% ethylene glycol and diethylene glycol
≤0.4% total ash
≤1 ppm ethylene oxide
≤1.0% water
≤2 ppm arsenic traces
≤20 ppm heavy metals
≤5 ppm dioxan
≤5 ppm propylene oxide
50-150 ppm butylhydroxytoluene
ign. residue
≤0.30%
color
APHA: ≤120, 50/50 in CH3OH
pH
5.0-7.5 (100 g/L in H2O)
6.0-7.5 (25 g/L in H2O)
CMC
0.48 mM
transition temp
cloud point >100 °C
HLB
>24
Quality Level
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Application
- P 188在牙科制剂中的稳定作用：研究P188对smartCrystal牙科用橙皮苷工业浓缩液的稳定作用，发现其可提高制剂的长期稳定性，有牙科治疗意义(Romero et al., 2015)。
Biochem/physiol Actions
Poloxamer 188广泛用作增稠剂和凝胶粘合剂。
Other Notes
Poloxamer 188是广泛的嵌段共聚物系列泊洛沙姆(poloxamer)的一种型号。
Legal Information
存储类别
11 - Combustible Solids
wgk
WGK 1
D J Bartley et al.
Veterinary parasitology, 187(3-4), 464-472 (2012-03-21)
Non-specific mechanisms involving ATP-binding cassette drug efflux transporters may play an important role in xenobiotic clearance in ovine gastro-intestinal nematodes. By using transporter inhibitors, the aim of this trial was to assess the possibility of increasing drug bioavailability in the
Xijun Zhang et al.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 31(6), 842-845 (2011-12-17)
This study examined the effect of P85 (a pluronic block copolymer) and microbubble (MB) ultrasound contrast agents under ultrasound irradiation on gene transfection and expression. The pEGFP plasmids that can encode enhanced green fluorescent protein (pEGFP) served as a report
Wanhua Feng et al.
Colloids and surfaces. B, Biointerfaces, 105, 43-50 (2013-01-29)
The interaction between bacteria and surfaces is central to many environmental, industrial and medical applications. Surfactants are commonly used in these applications and can potentially influence the bacterium/surface interaction. The effect of surfactants upon bacterial cell surface thermodynamic properties was
Neeta Jain-Gupta et al.
FEMS immunology and medical microbiology, 66(3), 436-444 (2012-11-21)
Brucellosis is the most common zoonotic disease worldwide, and there is no vaccine for human use. Brucella melitensis Rev1, a live attenuated strain, is the commercial vaccine for small ruminants to prevent B. melitensis infections but has been associated with abortions
A N Sklifas et al.
Biofizika, 57(2), 317-324 (2012-05-19)
The adsorption abilities of the perfluorocarbon emulsion stabilized by Proxanol 268 were investigated in vitro and in vivo. In vitro, the saturation point for the blood plasma proteins was nearly reached after five minutes of incubation of the emulsion with
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