SMILES string
O2C(C2)C.O1CC1
InChI
1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
InChI key
RVGRUAULSDPKGF-UHFFFAOYSA-N
form
powder
quality
purified
impurities
≤1.0% water
pH
5.0-7.5
solubility
soluble, clear, colorless
cation traces
Al: ≤5 mg/kg, As: ≤0.05 mg/kg, Ba: ≤5 mg/kg, Bi: ≤5 mg/kg, Ca: ≤50 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤1000 mg/kg, Li: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Sr: ≤5 mg/kg, Zn: ≤5 mg/kg
UV absorption
λ: 260 nm Amax: ≤0.3, λ: 280 nm Amax: ≤0..2
suitability
no residue for filter test
storage temp.
2-8°C
Quality Level
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General description
泊洛沙姆407是一种水溶性非离子表面活性剂，具有低毒性和良好的增溶能力。这种三嵌段共聚物由疏水的聚氧丙烯（POP）残基和两侧亲水的聚氧乙烯（POE）单元组成。
Application
泊洛沙姆407已被用于：
- 作为脂蛋白脂肪酶活性的抑制剂，以评估小鼠肝脏极低密度脂蛋白 (VLDL)-甘油三酯(TG)的分泌
- 用于小鼠VLDL分泌测定
- 溶解在磷酸盐缓冲盐水(PBS)中，通过腹膜内注射进小鼠以产生肝甘油三酯
Biochem/physiol Actions
泊洛沙姆407 （P407）在特定的聚合物浓度和温度以上表现出可逆的胶凝特性。泊洛沙姆407-基无菌注射制剂是药物传递的优秀候选物。P407热敏水凝胶广泛用作粘膜药物传递系统，因为它们不会刺激粘膜。P407被美国食品和药物管理局(FDA)称为“非活性成分”，适用于多种药物产品，如口服溶液、悬浮液和吸入制剂。
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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