16859
2-羟基-D-谷氨酸 二钠盐
≥98.0% (GC)
别名:
（R）-2-羟基戊二酸, （R）-2-羟基戊二酸二钠
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关于此项目
线性分子式:
C5H6O5Na2
化学文摘社编号:
分子量:
192.08
UNSPSC Code:
12352106
NACRES:
NA.25
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
5318041
InChI key
DZHFTEDSQFPDPP-HWYNEVGZSA-L
SMILES string
[Na].O[C@H](CCC(O)=O)C(O)=O
InChI
1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m1../s1
assay
≥98.0% (GC)
form
powder or crystals
optical activity
[α]/D 8.5±1.5°, c = 1 in NaOH
impurities
≤6.0% water
storage temp.
2-8°C
Quality Level
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Biochem/physiol Actions
代谢和癌症先天性错误的生物标志物
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Stefan Nowicki et al.
The FEBS journal, 282(15), 2796-2805 (2015-04-14)
Increased glucose metabolism in cancer cells is a phenomenon that has been known for over 90 years, allowing maximal cell growth through faster ATP production and redistribution of carbons towards nucleotide, protein and fatty acid synthesis. Recently, metabolites that can
Seth J Parker et al.
Pharmacology & therapeutics, 152, 54-62 (2015-05-10)
Specific point mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) occur in a variety of cancers, including acute myeloid leukemia (AML), low-grade gliomas, and chondrosarcomas. These mutations inactivate wild-type enzymatic activity and convey neomorphic function to produce d-2-hydroxyglutarate
Stereochemical studies on porphyrin a: assignment of the absolute configuration of a model porphyrin by degradation.
Battersby, A.R., et al.
Journal of the Chemical Society. Perkin Transactions 1, 9, 1565-1580 (1986)
Stereospecific ketonization of 2-hydroxymuconate by 4-oxalocrotonate tautomerase and 5-(carboxymethyl)-2-hydroxymuconate isomerase.
Whitman, C.P., et al.
Journal of the American Chemical Society, 114, 10104-10110 (1992)
Andrew J Worth et al.
Chemical research in toxicology, 28(5), 948-954 (2015-03-25)
The α-ketoglutarate metabolite, 2-hydroxyglutarate (2-HG), has emerged as an important mediator in a subset of cancers and rare inherited inborn errors of metabolism. Because of potential enantiospecific metabolism, chiral analysis is essential for determining the biochemical impacts of altered 2-HG
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