17928
O-Methyl-O′-succinylpolyethylene glycol 2′000
别名:
Polyethylene glycol, O-(Succinyl)-O′-methylpolyethylene glycol 2′000, Polyethylene glycol 2′000 monomethyl ether succinate
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关于此项目
线性分子式:
CH3O(CH2CH2O)nCOCH2CH2COOH
化学文摘社编号:
UNSPSC Code:
51171641
NACRES:
NA.26
MDL number:
form
powder
mol wt
Mr ~2100
mp
50-53 °C
Ω-end
carboxylic acid
α-end
methoxy
storage temp.
−20°C
Quality Level
Application
Polyethylene glycol 2000 is used in the construction of biomaterials such as biopolymers, micelles and nanostructures.
Biochem/physiol Actions
O-Methyl-O′-succinylpolyethylene glycol 2′000 is a modified monomethoxypolyethylene glycol (mPEG) wherein the hydroxyl groups are succinylated by succinic anhydride. This succinylated mPEG can then be used to synthesize tolerogenic mPEG conjugates of peptides. Tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Hattori Y, Nagaoka Y, Kubo M, et al.
Chemical & Pharmaceutical Bulletin, 59, 1389-1392 (2011)
Peter M Fischer et al.
Journal of peptide science : an official publication of the European Peptide Society, 8(9), 529-542 (2002-10-10)
Stepwise synthetic assembly of polypeptide chains reversibly linked to polyethylene glycol represents a hybrid between traditional solution and solid-phase chemistries and combines the inherent advantages of both approaches. The technical simplicity and scalability of the liquid-phase peptide synthesis method renders
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Gauthier MA, Klok HA.
Chemical Communications (Cambridge, England), 21, 2591-2611 (2008)
Sabrina Hoffmann et al.
Immunology letters, 136(1), 13-20 (2010-11-30)
T-cell recognition of peptide-MHC complexes on APCs requires cell-cell interactions. The molecular events leading to T-cell activation have been extensively investigated, but the underlying physical binding forces between T-cells and APCs are largely unknown. We used single cell force spectroscopy
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