17938
25-羟基维生素D3 一水合物
≥99.0% (HPLC)
别名:
25-羟基胆钙化醇
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关于此项目
经验公式（希尔记法）:
C27H44O2 · H2O
化学文摘社编号:
分子量:
418.65
NACRES:
NA.79
PubChem Substance ID:
eCl@ss:
34058003
UNSPSC Code:
12352205
MDL number:
Beilstein/REAXYS Number:
4270041
InChI
1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1
SMILES string
[H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C)[C@H](C)CCCC(C)(C)O
InChI key
JWUBBDSIWDLEOM-DTOXIADCSA-N
biological source
synthetic
assay
≥99.0% (HPLC)
form
powder or crystals
color
white to off-white
shipped in
dry ice
storage temp.
−20°C
Quality Level
Gene Information
human ... VDR(7421)
Biochem/physiol Actions
胆钙化醇是维生素D3的一种失活形式，它在经历各种水平的羟基化后可形成活性的维生素D3类似物。 1α-羟基维生素D3（α-骨化醇）是一种合成类似物，其可代谢为1,25-二羟胆钙化醇（维生素D3的生物活性形式）。胆钙化醇的其他类似物可由不同的羟基化产生。 25-二羟胆钙化醇是维生素D3的主要循环形式，是1α，25-二羟胆钙化醇的生理前体。该转化由25-羟基维生素D3 1-α-羟化酶（VD3 1A羟化酶）——也称为细胞色素p450 27B1 (CYP27B1)——进行催化。
Packaging
无底玻璃瓶。内容物包含在插入的融合锥内。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - STOT RE 1 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Matthew J Rowling et al.
The Journal of nutrition, 136(11), 2754-2759 (2006-10-24)
The major circulating form of vitamin D is 25-hydroxycholecalciferol [25(OH)D3], which is delivered to target tissues in complex with the serum vitamin D binding protein (DBP). We recently observed that mammary cells can metabolize 25(OH)D3 to 1,25-dihydroxycholecalciferol [1,25(OH)(2)D3], the vitamin
H F DeLuca
Biochemical Society transactions, 10(3), 147-158 (1982-06-01)
Cholecalciferol must be regarded as a pro-hormone rather than a vitamin, since it is normally produced in skin under the influence of ultraviolet light. Cholecalciferol must be metabolized in liver to 25-hydroxycholecalciferol and subsequently to 1,25-dihydroxycholecalciferol before it can act
Carly M Kemmis et al.
The Journal of nutrition, 136(4), 887-892 (2006-03-22)
1alpha,25-dihydroxycholecalciferol [1alpha,25(OH)2D3], the active form of cholecalciferol, is a negative growth regulator of breast cancer cells. CYP27B1 is a cytochrome P450-containing hydroxylase expressed in kidney and other tissues that generates 1alpha,25(OH)2D3 from an inactive vitamin D precursor 25-hydroxycholecalciferol [25(OH)D3]. In
Fadia S AlBuhairan et al.
The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 57(3), 263-269 (2015-08-25)
With the increasing burden of noncommunicable disease, adolescence is viewed as an opportune time to prevent the onset of certain behaviors and promote healthy states. Although adolescents comprise a considerable portion of Saudi Arabia's population, they have received insufficient attention
Marina V Antunes et al.
Therapeutic drug monitoring, 37(6), 733-744 (2015-04-09)
In view of the large variability on therapeutic response and the multiple factors associated to tamoxifen (TAM) metabolic activation, this study aimed to evaluate the effect of CYP2D6 and CYP3A4 phenotypes, drug interactions, and vitamin D exposure on TAM metabolism
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