17943
(24R)-24,25-二羟基维生素 D 3
≥98% (vitamin + pre-vitamin, HPLC)
别名:
24,25-二羟胆钙化醇, 司骨化醇
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关于此项目
经验公式（希尔记法）:
C27H44O3
化学文摘社编号:
分子量:
416.64
UNSPSC Code:
12352205
NACRES:
NA.79
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4567039
InChI
1S/C27H44O3/c1-18-8-12-22(28)17-21(18)11-10-20-7-6-16-27(5)23(13-14-24(20)27)19(2)9-15-25(29)26(3,4)30/h10-11,19,22-25,28-30H,1,6-9,12-17H2,2-5H3/b20-10+,21-11-/t19-,22+,23-,24+,25-,27-/m1/s1
SMILES string
[H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C)[C@H](C)CC[C@@H](O)C(C)(C)O
InChI key
FCKJYANJHNLEEP-XRWYNYHCSA-N
biological source
synthetic
assay
≥98% (vitamin + pre-vitamin, HPLC)
Quality Level
color
white to off-white
storage temp.
−20°C
General description
(24R)-24,25-二羟基维生素 D3（或称司骨化醇）在肾脏中产生。它是活性最高的维生素D形式之一，同时也是必需的循环维生素D3代谢产物。
Application
(24R)-24,25--二羟基维生素D3已被用于评估在原代人间充质干细胞（hMSC）的成骨细胞分化过程中，其与1α,25(OH)2D3的功能比较。
Biochem/physiol Actions
(24R)-24,25-二羟基维生素D3在钙和磷的稳态中起关键作用。(24R)-24,25--二羟基维生素D3与1α25（OH）2D3一起刺激骨代谢。
胆钙化醇是维生素D3的一种失活形式，它在经历各种水平的羟基化后可形成活性的维生素D3类似物。 1α-羟基维生素D3（骨化醇）是一种合成类似物，其可代谢为1,25-二羟胆钙化醇（维生素D3的生物活性形式）。胆钙化醇的其他类似物可由不同的羟基化产生。 24R,25-二羟基维生素D3是25-二羟基维生素D3的分解代谢产物，是发育性骨形成的推定调节剂（putative regulator）。24R,25-二羟基维生素D3是肾25-羟基维生素D3 1α-羟化酶的底物。24R,25-二羟基维生素D3是通过VDR非依赖性信号传导机制调节载脂蛋白A-I （apo A-I ）合成的内源性调节剂，也是通过Ca2 +、PLD和PLC信号传导以及通过LPA-LPA1/3-G(αi)-PI(3)K-mdm2介导的53降解起作用的 Pi诱导的细胞凋亡抑制剂。
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - STOT RE 1 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
T Sakaki et al.
European journal of biochemistry, 259(3), 731-738 (1999-03-27)
Renal 25-hydroxyvitamin D3 1 alpha-hydroxylase cDNA cloned from the kidneys of mice lacking the vitamin D receptor was expressed in Escherichia coli JM109. As expected, the bacterially-expressed enzyme catalyzes the 1 alpha-hydroxylation of 25-hydroxyvitamin D3 with a Michaelis constant, K(m)
Yanping Lin et al.
Current eye research, 37(10), 871-878 (2012-05-29)
This study was designed to measure vitamin D metabolites in the aqueous and vitreous humor and in tear fluid, and to determine if dietary vitamin D3 supplementation affects these levels. We also determined if the corneal epithelium can synthesize vitamin
24R, 25-Dihydroxyvitamin D3 and 1alpha, 25-dihydroxyvitamin D3 are both indispensable for calcium and phosphorus homeostasis
Norman AW, et al.
Life Sciences, 27(3), 229-237 (1980)
Hulya Taskapan
International urology and nephrology, 44(4), 1135-1144 (2012-04-03)
Deficiency of 1,25-dihydroxyvitamin D [1,25(OH)(2)D] and excessive fibroblast growth factor (FGF23) are suggested to be associated with increased mortality in patients with chronic kidney disease (CKD). Generally, 24-hydroxylation has been considered the first step in the degradation pathway of 1,25(OH)(2)D
J D Bashutski et al.
Journal of dental research, 90(8), 1007-1012 (2011-05-11)
Vitamin D regulates calcium and immune function. While vitamin D deficiency has been associated with periodontitis, little information exists regarding its effect on wound healing and periodontal surgery outcomes. This longitudinal clinical trial assessed outcomes of periodontal surgery and teriparatide
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