18726
Nα-Methyl-L-ornithine monohydrochloride
≥98% (TLC), powder
别名:
(S)-5-Amino-2-(methylamino)pentanoic acid hydrochloride, N-Me-Orn-OH · HCl
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关于此项目
经验公式（希尔记法）:
C6H14N2O2 · HCl
化学文摘社编号:
分子量:
182.65
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Beilstein/REAXYS Number:
6117952
产品名称
Nα-Methyl-L-ornithine monohydrochloride, ≥98% (TLC)
SMILES string
Cl.CN[C@@H](CCCN)C(O)=O
InChI key
OUPNMQRLBAANLP-JEDNCBNOSA-N
InChI
1S/C6H14N2O2.ClH/c1-8-5(6(9)10)3-2-4-7;/h5,8H,2-4,7H2,1H3,(H,9,10);1H/t5-;/m0./s1
assay
≥98% (TLC)
form
powder
optical activity
[α]/D +27.0±1.0°, c = 1 in 1 M HCl
composition
carbon, 38.7-40.2% , nitrogen, 14.9-15.7%
Quality Level
Biochem/physiol Actions
Nα-Methyl-L-ornithine has been identified as an inhibitor of nitric oxidase synthase in macrophages.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
T B McCall et al.
British journal of pharmacology, 102(1), 234-238 (1991-01-01)
1. The synthesis of nitric oxide (NO) from L-arginine by rat peritoneal neutrophils (PMN) and the murine macrophage cell-line J774 and the inhibition of this synthesis by N-iminoethyl-L-ornithine (L-NIO), NG-monomethyl-L-arginine (L-NMMA), NG-nitro-L-arginine (L-NNA) and its methyl ester (L-NAME) were investigated.
D J Gordon et al.
Biochemistry, 40(28), 8237-8245 (2001-07-11)
A potential goal in the prevention or therapy of Alzheimer's disease is to decrease or eliminate neuritic plaques composed of fibrillar beta-amyloid (Abeta). In this paper we describe N-methyl amino acid containing congeners of the hydrophobic "core domain" of Abeta
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