19176
DL -丁硫氨酸亚砜亚胺
synthetic, ≥99.0% (TLC), glutathione biosynthesis inhibitor, powder or crystals
别名:
DL-Buthionine (S,R)-sulfoximine, BSO, Buthionine sulfoximine, Butionine sulfoximine
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关于此项目
经验公式（希尔记法）:
C8H18N2O3S
化学文摘社编号:
分子量:
222.31
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Beilstein/REAXYS Number:
2367136
产品名称
DL -丁硫氨酸亚砜亚胺, ≥99.0% (TLC)
InChI
1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)
SMILES string
CCCCS(=N)(=O)CCC(N)C(O)=O
InChI key
KJQFBVYMGADDTQ-UHFFFAOYSA-N
biological source
synthetic
assay
≥99.0% (TLC)
form
powder or crystals
mp
215 °C
solubility
H2O: 50 mg/mL, clear to almost clear, colorless
storage temp.
2-8°C
Quality Level
Application
DL-丁硫氨酸-亚砜亚胺适用于：
- 检测 BSO 抑制谷胱甘肽是否增强雌激素对抗激素抵抗性人乳腺癌细胞的凋亡作用
- 研究 BSO 对牛胚胎发育的影响
- 在多项研究中抑制 GSH
- GSH 合成对卵母细胞成熟的影响
Biochem/physiol Actions
丁硫氨酸亚砜亚胺抑制肝脏和其他外周器官谷胱甘肽 (GSH) 的生物合成。对 CNS 中 GSH 无任何影响。增强活性氧（如过氧化氢）和间接引起活性氧蓄积的药物（如 2-甲氧基雌二醇，增加细胞内超氧阴离子）操作抗增殖作用。
Other Notes
耗尽分离细胞中的谷胱甘肽
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Evaluation of hepatotoxicity and nephrotoxicity of natural food colorants in mice depleted of glutathione by DL-buthionine sulfoximine.
Kawazoe S, et al.
Journal of Health Science, 46, 56- 58 (2000)
Joan S Lewis-Wambi et al.
Breast cancer research : BCR, 10(6), R104-R104 (2008-12-09)
Estrogen deprivation using aromatase inhibitors is one of the standard treatments for postmenopausal women with estrogen receptor (ER)-positive breast cancer. However, one of the consequences of prolonged estrogen suppression is acquired drug resistance. Our group is interested in studying antihormone
Yuka Hirai et al.
Biological & pharmaceutical bulletin, 29(5), 1064-1067 (2006-05-03)
2-Methoxyestradiol (2-ME), an endogenous metabolite of 17beta-estradiol, induces the intracellular accumulation of superoxide anion (O2*-) and buthionine sulfoximine (BSO) is an inhibitor of glutathione (GSH) synthesis. We have examined the combination anticancer effect of 2-ME and BSO accompanied with hydrogen
A Slivka et al.
Journal of neurochemistry, 50(5), 1391-1393 (1988-05-01)
Previous studies indicated that DL-buthionine sulfoximine (DL-BSO), an agent that inhibits the biosynthesis of GSH in liver and other peripheral organs, fails to suppress levels of GSH in the CNS. In the current study, preweanling mice responded to repeated injections
M A Baker et al.
Analytical biochemistry, 190(2), 360-365 (1990-11-01)
By combining the least complicated and expedient methods of sample handling with the sensitivity and specificity of the GSH assay by enzymatic recycling and the small volumes and software capabilities of microtiter plate technology we have devised a rapid, sensitive
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