19176
DL -丁硫氨酸亚砜亚胺
synthetic, ≥99.0% (TLC), glutathione biosynthesis inhibitor, powder or crystals
别名:
DL-Buthionine (S,R)-sulfoximine, BSO, Buthionine sulfoximine, Butionine sulfoximine
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关于此项目
经验公式（希尔记法）:
C8H18N2O3S
化学文摘社编号:
分子量:
222.31
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Beilstein/REAXYS Number:
2367136
产品名称
DL -丁硫氨酸亚砜亚胺, ≥99.0% (TLC)
InChI
1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)
SMILES string
CCCCS(=N)(=O)CCC(N)C(O)=O
InChI key
KJQFBVYMGADDTQ-UHFFFAOYSA-N
biological source
synthetic
assay
≥99.0% (TLC)
form
powder or crystals
mp
215 °C
solubility
H2O: 50 mg/mL, clear to almost clear, colorless
storage temp.
2-8°C
Quality Level
Application
DL-丁硫氨酸-亚砜亚胺适用于：
- 检测 BSO 抑制谷胱甘肽是否增强雌激素对抗激素抵抗性人乳腺癌细胞的凋亡作用
- 研究 BSO 对牛胚胎发育的影响
- 在多项研究中抑制 GSH
- GSH 合成对卵母细胞成熟的影响
Biochem/physiol Actions
丁硫氨酸亚砜亚胺抑制肝脏和其他外周器官谷胱甘肽 (GSH) 的生物合成。对 CNS 中 GSH 无任何影响。增强活性氧（如过氧化氢）和间接引起活性氧蓄积的药物（如 2-甲氧基雌二醇，增加细胞内超氧阴离子）操作抗增殖作用。
Other Notes
耗尽分离细胞中的谷胱甘肽
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
N Yamauchi et al.
Biology of reproduction, 61(3), 828-833 (1999-08-24)
The present study was conducted to examine effects of cysteamine in culture medium on progression of meiosis, glutathione (GSH) content, kinase activities (histone H1 kinase and mitogen-activated protein kinase), and male pronuclear formation after in vitro insemination of cumulus-denuded oocytes
M Takahashi et al.
Biology of reproduction, 49(2), 228-232 (1993-08-01)
The purpose of this investigation was to determine the effect of beta-mercaptoethanol (beta-ME) and cysteamine, low-molecular-weight thiol compounds, on the development and intracellular glutathione content of bovine embryos obtained by in vitro fertilization of in vitro-matured oocytes. Embryos developed to
Jong-Shyan Wang et al.
European journal of applied physiology, 95(4), 290-297 (2005-08-13)
Exercise is linked with intensity-dependent immune response. Intracellular redox status is important in programmed cell death. This study, by closely examining 18 sedentary men who exercised moderately and severely (ie. 60% and 80% VO2max, respectively) for 40 min, investigated how
Sophia Fried et al.
Scientific reports, 10(1), 7599-7599 (2020-05-07)
Biliary atresia is a neonatal liver disease with extrahepatic bile duct obstruction and progressive liver fibrosis. The etiology and pathogenesis of the disease are unknown. We previously identified a plant toxin, biliatresone, responsible for biliary atresia in naturally-occurring animal models
Christine Syng-Ai et al.
Molecular cancer therapeutics, 3(9), 1101-1108 (2004-09-16)
Curcumin, a well-known dietary pigment derived from Curcuma longa, inhibited growth of several types of malignant cells both in vivo and in vitro. However, its mechanism of action still remains unclear. In this study, we have focused primarily on the
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