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关于此项目
经验公式(希尔记法):
C12H15N3O3S
化学文摘社编号:
分子量:
281.33
PubChem Substance ID:
UNSPSC Code:
51101500
Beilstein/REAXYS Number:
677664
MDL number:
SMILES string
CCCS(=O)c1ccc2[nH]c(NC(=O)OC)nc2c1
InChI
1S/C12H15N3O3S/c1-3-6-19(17)8-4-5-9-10(7-8)14-11(13-9)15-12(16)18-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
InChI key
VXTGHWHFYNYFFV-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
colorless to white
antibiotic activity spectrum
neoplastics, parasites
mode of action
DNA synthesis | interferes, enzyme | interferes, protein synthesis | interferes
General description
化学结构:苯并咪唑
Application
利苯达达唑是具有广谱驱虫活性的氨基甲酸甲酯苯并咪唑。阿糖达唑是阿苯达唑的关键代谢产物。研究表明它可能通过使细胞周期停滞在G2/M 期而诱导人癌细胞 HT-29 凋亡。
Biochem/physiol Actions
罗苯达唑是阿苯达唑的关键代谢产物,并作为驱虫药。研究表明,它可能通过使细胞周期停滞在 G2/M 期而诱导人癌细胞 HT-29 凋亡。
Packaging
25G
Other Notes
将容器密闭保存在干燥和通风良好的地方。在干燥处保存。
signalword
Warning
hcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - Skin Sens. 1 - STOT RE 2 Oral
target_organs
Adrenal gland,spleen,male reproductive organs,Blood
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Gracia Merino et al.
Drug metabolism and disposition: the biological fate of chemicals, 33(5), 614-618 (2005-02-11)
Methylcarbamate benzimidazoles [albendazole (ABZ), fenbendazole (FBZ), and their respective sulfoxide derivatives, albendazole sulfoxide (ABZSO) and oxfendazole (OXF)] are therapeutically important anthelmintic agents with low bioavailability. We studied their in vitro interaction with the apical ATP-binding cassette (ABC) drug efflux transporters
Mohammad H Pourgholami et al.
Cancer chemotherapy and pharmacology, 55(5), 425-432 (2004-11-27)
The peritoneal surface remains an important failure site for patients with colorectal cancer. We have recently shown that albendazole (ABZ), a safe and effective anthelmintic drug, has profound antitumor activity in hepatocellular cancer. Furthermore, albendazole also possesses unique physiochemical and
Kátia Roberta A Belaz et al.
Journal of pharmaceutical and biomedical analysis, 66, 100-108 (2012-04-11)
Analytical and semipreparative high performance liquid chromatography methods using polysaccharide-based chiral stationary phases were developed for the enantiomeric resolution of albendazol sulfoxide. The enantioseparation of this compound was evaluated with four chiral stationary phases: cellulose and amylose tris(3,5-dimethylphenylcarbamate), amylose tris[(S)-1-phenylethylcarbamate]
Daniel B Carrão et al.
Electrophoresis, 32(19), 2746-2756 (2011-09-10)
Hollow fiber liquid-phase microextraction and CE were applied for the determination of albendazole sulfoxide (ASOX) enantiomers in liquid culture medium after a fungal biotransformation study. The analytes were extracted from 1 mL of liquid culture medium spiked with the internal
L Alvarez et al.
Journal of veterinary pharmacology and therapeutics, 35(4), 365-372 (2011-08-09)
The gastrointestinal absorption of most drugs follows a first-order kinetics, whereby a constant fraction of the total drug is absorbed in each equal time interval. Although this related absorption principle is applicable to the most of the therapeutically used drugs
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