19953
阿苯达唑亚砜
≥98% (HPLC)
别名:
[5-（丙烷-1-亚磺酰基）-1H-苯并咪唑-2-基]-氨基甲酸甲酯, 氧阿苯达唑, 阿苯达唑亚砜
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关于此项目
经验公式（希尔记法）:
C12H15N3O3S
化学文摘社编号:
分子量:
281.33
PubChem Substance ID:
UNSPSC Code:
51101500
Beilstein/REAXYS Number:
677664
MDL number:
assay
≥98% (HPLC)
form
powder
color
colorless to white
antibiotic activity spectrum
neoplastics, parasites
mode of action
DNA synthesis | interferes, enzyme | interferes, protein synthesis | interferes
SMILES string
CCCS(=O)c1ccc2[nH]c(NC(=O)OC)nc2c1
InChI
1S/C12H15N3O3S/c1-3-6-19(17)8-4-5-9-10(7-8)14-11(13-9)15-12(16)18-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
InChI key
VXTGHWHFYNYFFV-UHFFFAOYSA-N
General description
化学结构：苯并咪唑
Application
利苯达达唑是具有广谱驱虫活性的氨基甲酸甲酯苯并咪唑。阿糖达唑是阿苯达唑的关键代谢产物。研究表明它可能通过使细胞周期停滞在G2/M 期而诱导人癌细胞 HT-29 凋亡。
Biochem/physiol Actions
罗苯达唑是阿苯达唑的关键代谢产物，并作为驱虫药。研究表明，它可能通过使细胞周期停滞在 G2/M 期而诱导人癌细胞 HT-29 凋亡。
Packaging
25G
Other Notes
将容器密闭保存在干燥和通风良好的地方。在干燥处保存。
signalword
Warning
hcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - Skin Sens. 1 - STOT RE 2 Oral
target_organs
Adrenal gland,spleen,male reproductive organs,Blood
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Mohammad H Pourgholami et al.
Cancer chemotherapy and pharmacology, 55(5), 425-432 (2004-11-27)
The peritoneal surface remains an important failure site for patients with colorectal cancer. We have recently shown that albendazole (ABZ), a safe and effective anthelmintic drug, has profound antitumor activity in hepatocellular cancer. Furthermore, albendazole also possesses unique physiochemical and
Gracia Merino et al.
Drug metabolism and disposition: the biological fate of chemicals, 33(5), 614-618 (2005-02-11)
Methylcarbamate benzimidazoles [albendazole (ABZ), fenbendazole (FBZ), and their respective sulfoxide derivatives, albendazole sulfoxide (ABZSO) and oxfendazole (OXF)] are therapeutically important anthelmintic agents with low bioavailability. We studied their in vitro interaction with the apical ATP-binding cassette (ABC) drug efflux transporters
Hana Bártíková et al.
Veterinary parasitology, 176(1), 27-33 (2010-11-16)
Albendazole (ABZ) is one of the most important benzimidazole compounds possessing high activity against the lancet fluke, Dicrocoelium dendriticum. ABZ sulphoxide (ABZ.SO) is the main molecule present in the bloodstream of an ABZ-treated host. The aim of this study was
Kátia Roberta A Belaz et al.
Journal of pharmaceutical and biomedical analysis, 66, 100-108 (2012-04-11)
Analytical and semipreparative high performance liquid chromatography methods using polysaccharide-based chiral stationary phases were developed for the enantiomeric resolution of albendazol sulfoxide. The enantioseparation of this compound was evaluated with four chiral stationary phases: cellulose and amylose tris(3,5-dimethylphenylcarbamate), amylose tris[(S)-1-phenylethylcarbamate]
Daniel B Carrão et al.
Electrophoresis, 32(19), 2746-2756 (2011-09-10)
Hollow fiber liquid-phase microextraction and CE were applied for the determination of albendazole sulfoxide (ASOX) enantiomers in liquid culture medium after a fungal biotransformation study. The analytes were extracted from 1 mL of liquid culture medium spiked with the internal
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| CDS003635-250MG | 04061829099688 |
| BOG00118-1G | 04061825134246 |
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