biological source
rabbit
conjugate
unconjugated
antibody form
Ig fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (223A-14), vial of 0.5 mL concentrate (223A-15), bottle of 1.0 mL predilute (223A-17), vial of 1.0 mL concentrate (223A-16), bottle of 7.0 mL predilute (223A-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500-1:2000
control
tonsil
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic
General description
Alpha-1-Antitrypsin is a protease inhibitor from the serpin superfamily, which inhibits a number of protease enzymes from inflammatory cells. It is an acute-phase plasma protein predominantly produced in hepatocytes, although it is also made in enterocytes and some mononuclear white blood cells. Alpha-1-antitrypsin immunohistochemistry is used to detect the accumulation of alpha-1-antitrypsin in hepatic lesions and histiocytic tumors.
The immunohistochemical staining of Alpha-1-Antitrypsin is considered to be very useful in the study of inherited AAT deficiency, benign and malignant hepatic tumors, and yolk sac carcinomas. Positive staining for A-1-Antitrypsin may also be used in the detection of benign and malignant lesions of a histiocytic nature. The sensitivity and specificity of the results have made this antibody a useful tool in the screening of patients with cryptogenic cirrhosis or other forms of liver disease with portal fibrosis of uncertain etiology.
The immunohistochemical staining of Alpha-1-Antitrypsin is considered to be very useful in the study of inherited AAT deficiency, benign and malignant hepatic tumors, and yolk sac carcinomas. Positive staining for A-1-Antitrypsin may also be used in the detection of benign and malignant lesions of a histiocytic nature. The sensitivity and specificity of the results have made this antibody a useful tool in the screening of patients with cryptogenic cirrhosis or other forms of liver disease with portal fibrosis of uncertain etiology.
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Analysis Note
 IVD |  IVD |  IVD |  RUO |
Other Notes
A-1-Antitrypsin Positive Control Slides , Product No. 223S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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H Takahashi et al.
Acta pathologica japonica, 40(9), 655-664 (1990-09-01)
Fifty-four adenoid cystic carcinomas (ACC) arising in major and minor salivary glands as well as in normal salivary glands were studied by immunohistochemistry for the presence of vimentin, neuron-specific enolase (NSE), alpha 1-antichymotrypsin (alpha 1-ACT) and alpha 1-antitrypsin (alpha 1-AT).
B Lindmark et al.
Histopathology, 16(3), 221-225 (1990-03-01)
We present a case of chronic liver disease with selective and exclusive hepatocyte endoplasmic reticulum storage of alpha 1-antichymotrypsin in the form of granules, detected by specific immunohistochemistry at the light microscopy level and corresponding to material found in dilated
L G Kindblom et al.
Human pathology, 13(9), 834-840 (1982-09-01)
The aim of this study was to localize alpha 1-antitrypsin, ferritin, and lysozyme by means of the indirect immunoperoxidase technique and to evaluate the significance of these antigens as markers of histiocytic differentiation in tumors of a supposed dual fibroblastic-histiocytic
Expression of protein markers in malignant hepatoma: evidence for genetic and epigenetic mechanisms.
P E Palmer et al.
Cancer, 45(6), 1424-1431 (1980-03-15)
Jun Nishio et al.
Human pathology, 34(3), 246-252 (2003-04-04)
Undifferentiated (embryonal) sarcoma of the liver (UESL) is a rare pediatric liver malignancy that is extremely uncommon in middle-aged individuals. We studied 2 cases of UESL in middle-aged adults (1 case in a 49-year-old woman and the other in a
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