hCG Rabbit Polyclonal Antibody

Human chorionic gonadotropin (hCG) is a hormone synthesized by syncytiotrophoblasts and belongs to a group of glycoprotein hormones known as gonadotropins. Gonadotropins regulate normal growth, sexual development, and reproductive function. This antibody detects syncytiotrophoblasts in placenta and in tumors such as choriocarcinoma and some cases of seminoma.
hCG is a protein secreted in large quantities by normal trophoblasts; the antibody detects cells and tumors of trophoblastic origin such as choriocarcinoma. Large cell carcinoma and adenocarcinoma of the lung demonstrate anti-hCG positivity in 90% and 60% of cases respectively. 20% of lung squamous cell carcinomas are positive for anti-hCG. hCG expression by non-trophoblastic tumors may indicate aggressive behavior since it has been observed that hCG may play a role in the host response to a given tumor.

hCG Positive Control Slides, Product No. 234S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

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