238422
2-溴十六烷酸
~97%, PPARδ agonist, solid
别名:
2-溴棕榈酸
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关于此项目
线性分子式:
CH3(CH2)13CH(Br)CO2H
CAS Number:
分子量:
335.32
Beilstein:
1726517
EC 号:
MDL编号:
UNSPSC代码:
12352203
PubChem化学物质编号:
NACRES:
NA.77
Product Name
2-溴十六烷酸, ~97%
方案
~97%
质量水平
表单
solid
SMILES字符串
CCCCCCCCCCCCCCC(Br)C(O)=O
InChI
1S/C16H31BrO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(17)16(18)19/h15H,2-14H2,1H3,(H,18,19)
InChI key
DPRAYRYQQAXQPE-UHFFFAOYSA-N
基因信息
human ... PPARD(5467)
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相关类别
一般描述
PPARδ（过氧化物酶体增殖物激活受体，δ 同种型）作为基因表达的一种转录因子，并在脂质代谢调节中发挥作用；该受体的活性受配体调节。2-溴十六烷酸是脂肪酸棕榈酸的代谢稳定的类似物，已被证明是 PPARδ 受体的天然配体。2-溴十六烷酸也已被用在脂肪酸氧化、棕榈酰化和葡萄糖摄取的研究中。
生化/生理作用
溴十六烷酸是 PPARδ 激动剂。它还显示抑制脂肪酸氧化，抑制 DHHC 介导的棕榈酰化，并促进大鼠心脏细胞和胰岛素敏感的鼠成纤维细胞系 A31-IS 中的葡萄糖摄取。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
235.4 °F - closed cup
闪点(°C)
113 °C - closed cup
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Joel Berger et al.
Annual review of medicine, 53, 409-435 (2002-01-31)
The peroxisome proliferator-activated receptors (PPARs) are a group of three nuclear receptor isoforms, PPAR gamma, PPAR alpha, and PPAR delta, encoded by different genes. PPARs are ligand-regulated transcription factors that control gene expression by binding to specific response elements (PPREs)
Kenji Hayata et al.
Journal of pharmacological sciences, 108(3), 348-354 (2008-11-15)
To obtain compounds that promote glucose uptake in muscle cells, the novel cell lines A31-IS derived from Balb/c 3T3 A31 and C2C12-IS from mouse myoblast C2C12 were established. In both cell lines, glucose consumption was induced by insulin and suppressed
Benjamin C Jennings et al.
Journal of lipid research, 50(2), 233-242 (2008-10-02)
Pharmacologic approaches to studying palmitoylation are limited by the lack of specific inhibitors. Recently, screens have revealed five chemical classes of small molecules that inhibit cellular processes associated with palmitoylation (Ducker, C. E., L. K. Griffel, R. A. Smith, S.
Priyanka Tripathi et al.
Journal of lipid research, 62, 100021-100021 (2021-01-01)
Microtubules are polymers composed of αβ-tubulin subunits that provide structure to cells and play a crucial role in in the development and function of neuronal processes and cilia, microtubule-driven extensions of the plasma membrane that have sensory (primary cilia) or
Wei Yuan et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(13) (2021-03-24)
The homeostasis of protein palmitoylation and depalmitoylation is essential for proper physiological functions in various tissues, in particular the central nervous system (CNS). The dysfunction of PPT1 (PPT1-KI, infantile neuronal ceroid lipofuscinosis [INCL] mouse model), which catalyze the depalmitoylation process
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