biological source
mouse
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
LK2H10, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (238M-94)
vial of 0.5 mL concentrate (238M-95)
bottle of 1.0 mL predilute (238M-97)
vial of 1.0 mL concentrate (238M-96)
bottle of 7.0 mL predilute (238M-98)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
isotype
IgG1κ
control
pancreas
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic
Gene Information
human ... CHGA(1113)
Analysis Note
 IVD |  IVD |  IVD |  RUO |
General description
Immunohistochemical methods have localized chromogranin in a wide variety of endocrine tissues including the pituitary, pancreas, hypothalamus, thymus, thyroid, intestine, and parathyroid. Neuroendocrine cells exhibit a fine granular immunoreactivity to chromogranin. It is generally accepted that the co-expression of certain keratins and chromogranin mean neuroendocrine lineage. The presence of strong chromogranin staining and absence of keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.
Other Notes
Chromogranin A Positive Control Slides, Product No. 238S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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D T O'Connor et al.
Life sciences, 33(17), 1657-1663 (1983-10-24)
Chromogranin A is the major soluble protein co-stored and co-released with catecholamines from catecholamine storage vesicles of adrenal medulla and sympathetic nerve. We recently described a widespread distribution of chromogranin, by radioimmunoassay, in all polypeptide hormone producing tissues. To define
G Qvigstad et al.
The Histochemical journal, 32(9), 551-556 (2000-12-29)
Neuroendocrine cells are often disclosed in human gastric adenocarcinomas and may be recognised by their immunoreactivity towards chromogranin A. However, in dedifferentiated neuroendocrine tumour cells, the chromogranin A content may be reduced making it difficult to detect with conventional immunohistochemical
A M Bofin et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 110(9), 658-664 (2003-01-17)
The aim of the study was to determine if, by means of tyramide signal amplification (TSA), the presence of chromogranin A (CgA)-positive tumour cells could be demonstrated in breast cancer cases found to be negative by conventional immunohistochemical staining. Sections
G J Kontochristopoulos et al.
Dermatology (Basel, Switzerland), 201(2), 123-126 (2000-10-29)
Although Merkel cell carcinoma (MCC) exhibits specific clinical and histologic features, differentiation from other cutaneous neoplasms, such as lymphoma, metastatic oat cell carcinoma and malignant melanoma (MM), may sometimes be difficult. The aim of our study was to immunohistochemically differentiate
R Fischer-Colbrie et al.
Neuroscience, 16(3), 547-555 (1985-11-01)
Bovine chromaffin granules contain two major families of acidic proteins, chromogranins A and B. The occurrence of these proteins in endocrine and nervous tissue was investigated by immunoblotting (one- and two-dimensional), and by immunohistochemistry. Immunoblotting revealed that in anterior hypophysis
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结直肠癌是男性和女性中第三大常见癌症。预计2016年将发生136,000例结直肠癌。
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