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Merck
CN

259A-1

Sigma-Aldrich

胰高血糖素

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关于此项目

UNSPSC代码:
12352203
NACRES:
NA.41
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生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

Ig fraction of antiserum

抗体产品类型

primary antibodies

克隆

polyclonal

描述

For In Vitro Diagnostic Use in Select Regions (See Chart)

表单

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (259A-14)
vial of 0.5 mL concentrate (259A-15)
bottle of 1.0 mL predilute (259A-17)
vial of 1.0 mL concentrate (259A-16)
bottle of 7.0 mL predilute (259A-18)

制造商/商品名称

Cell Marque®

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

控制

pancreas

运输

wet ice

储存温度

2-8°C

可视化

cytoplasmic

基因信息

human ... GCG(2641)

一般描述

The normal islets of Langerhans (pancreas) contain four major cell types, 15-20% of which are alpha cells which produce glucagon. Alpha cell tumors can be divided into two distinct types; those associated with glucagonoma syndrome (necrolytic migratory erythema, diabetes, anemia, stomatitis, weight loss, venous thromboses, diarrhea, and sometimes psychiatric disturbances), and those which are not. Those associated with the syndrome tend to be large and solitary and there is a high incidence of malignancy. Those glucagonomas not associated with the syndrome tend to be multiple and small and are nearly always benign.Immunohistochemically, the two types of glucagonoma are reactive to the glucagon antibody, though occasionally only weakly.

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

制备说明

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

分析说明


IVD

IVD

IVD

RUO

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Glucagon (polyclonal) Positive Control Slides, Product No. 259S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

法律信息

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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分析证书(COA)

Lot/Batch Number

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访问文档库

Diagnostic Immunohistochemistry: Theranostic and Genomic Applications (2010)
Aixia Sun et al.
Transplantation direct, 10(7), e1658-e1658 (2024-06-17)
Transplantation of human-induced pluripotent stem cell (hiPSC)-derived islet organoids is a promising cell replacement therapy for type 1 diabetes (T1D). It is important to improve the efficacy of islet organoids transplantation by identifying new transplantation sites with high vascularization and
Rosai and Ackerman's Surgical Pathology, 10th ed., 1030-1031 (2011)
Q A Hamid et al.
Histopathology, 10(2), 119-133 (1986-02-01)
Histological diagnosis of neuroendocrine tumours can be hampered by their lack of peptide or amine immunoreactivity. In order to assess the usefulness of a range of specific and general markers of neuroendocrine differentiation, 10 pancreatic endocrine tumours, associated with high
Yang Xiao et al.
Diabetologia, 66(6), 1142-1155 (2023-03-15)
Glucagon-stimulated hepatic gluconeogenesis contributes to endogenous glucose production during fasting. Recent studies suggest that TGF-β is able to promote hepatic gluconeogenesis in mice. However, the physiological relevance of serum TGF-β levels to human glucose metabolism and the mechanism by which

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