biological source
rabbit
conjugate
unconjugated
antibody form
Ig fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (270A-14)
vial of 0.5 mL concentrate (270A-15)
bottle of 1.0 mL predilute (270A-17)
vial of 1.0 mL concentrate (270A-16)
bottle of 7.0 mL predilute (270A-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
control
tonsil
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic
Analysis Note
 IVD |  IVD |  IVD |  RUO |
General description
Anti-IgM antibody reacts with surface immunoglobulin IgM mu chains. IgM is one of the predominant surface immunoglobulins on B-lymphocytes. This antibody is useful when identifying lymphomas, plasmacytomas, and B-cell lineage derived Hodgkin′s lymphomas. Due to the restricted expression of heavy and light chains in these diseases, demonstration of B-cell lymphomas is possible with clonal gene rearrangement studies.
Other Notes
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
IgM (polyclonal) Positive Control Slides, Product No. 270S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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Tissue section immunologic methods in lymphomas
Warnake, R., et al.
Diagnostic Immunohistochemistry (Masson Publishing), 203-221 (1981)
Manual of Diagnostic Antibodies for Immunohistology, 217-219 (1999)
C J de Boer et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 8 Suppl 2, 109-117 (1997-01-01)
Mantle-cell lymphoma comprises 2%-10% of all non-Hodgkin's lymphomas (NHLs). Patients present with generalized disease, and have a poor prognosis. Three different histologic patterns (mantle zone, nodular, and diffuse) and three different cytological variants (classical, blastic, and pleomorphic) have been described.
Masaru Kojima et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 110(12), 875-880 (2003-03-21)
Nodal marginal zone B-cell lymphomas (NMZBL) occasionally represent prominent plasma cell differentiation. Recently, we presented a patient with NMZBL who exhibited histological features that resembled plasmacytoma arising from a localized plasma cell variant of Castleman's disease. To further clarify the
S E Pambuccian et al.
The American journal of surgical pathology, 21(2), 179-186 (1997-02-01)
Tumoral amyloidosis (amyloidoma) of bone is a rare condition characterized by the massive destructive deposition of AL amyloid in bones. We report three cases. The patients ranged in age from 45 to 78 years and had tumors located in the
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