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Merck
CN

275R-3

Sigma-Aldrich

Ki-67 (MRQ-64) Rabbit Monoclonal Antibody

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UNSPSC代码:
12352203

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生物来源

rabbit

质量水平

100
500

偶联物

unconjugated

抗体形式

culture supernatant

抗体产品类型

primary antibodies

克隆

MRQ-64, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions

表单

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (275R-34)
vial of 0.1 mL concentrate Research Use Only (275R-34-RUO)
vial of 0.5 mL concentrate (275R-35)
vial of 1.0 mL concentrate (275R-36)
vial of 1.0 mL concentrate Research Use Only (275R-36-RUO)
vial of 1.0 mL pre-dilute Research Use Only (275R-37-RUO)
vial of 1.0 mL pre-dilute ready-to-use (275R-37)
vial of 25.0 mL pre-dilute ready-to-use (275R-30)
vial of 25.0 mL pre-dilute ready-to-use Research Use Only (275R-30-RUO)
vial of 7.0 mL pre-dilute ready-to-use (275R-38)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (275R-38-RUO)

制造商/商品名称

Cell Marque®

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

同位素/亚型

IgG

控制

Burkitt lymphoma, breast (ductl carcinoma in situ), tonsil

运输

wet ice

储存温度

2-8°C

可视化

nuclear

基因信息

human ... MKI67(4288)

相关类别

一般描述

Ki-67 (MRQ-64) is an antibody designed to target Ki-67 antigen-a nuclear protein encoded by the MKI67 gene whose presence correlates with G1, S, G2, and the mitotic phases of the cell cycle.1 Though its specific role is largely postulated and still yet to be determined, Ki-67′s presence during cellular division makes it an excellent target for labeling rapidly growing malignancies.2 Given that its presence correlates with cell proliferation, the immunohistochemical labeling of Ki-67 antigen may be useful in characterizing a lesion′s growth fraction. It has been demonstrated that identifying this antigen by IHC is useful in characterizing lesions of the breast, lymphoid cells, astrocytes, and uterus.3-9

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

制备说明

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分析说明

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Ki-67 Positive Control Slides, Product No. 275S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

法律信息

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000452091
0000452091
0000427175
0000427175
0000414947

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Adi Broyde et al.
American journal of hematology, 84(6), 338-343 (2009-04-23)
Expression of Ki-67, a nuclear antigen protein present in all cycling cells, is used to determine the growth fraction of tumors. The aim of this study was to evaluate the role and prognostic significance of the Ki-67 proliferation index (PI)
E C Inwald et al.
Breast cancer research and treatment, 139(2), 539-552 (2013-05-16)
The proliferation marker Ki-67 is one of the most controversially discussed parameters for treatment decisions in breast cancer patients. The purpose of this study was to evaluate the routine use and value of Ki-67 as a prognostic marker, and to
Shih-Sung Chuang et al.
American journal of clinical pathology, 128(4), 558-564 (2007-09-19)
Burkitt lymphoma (BL) is characterized by c-myc translocation and CD10+/bc-2-/bcl-6+ with a very high Ki-67 proliferation index (PI). Occasional diffuse large B-cell lymphomas may exhibit a very high PI with or without a starry-sky pattern (DLBCL-HPSS). We compared 28 consecutive
Xiaoming Sun et al.
Chromosoma, 127(2), 175-186 (2018-01-13)
Ki-67 protein has been widely used as a proliferation marker for human tumor cells for decades. In recent studies, multiple molecular functions of this large protein have become better understood. Ki-67 has roles in both interphase and mitotic cells, and
Nandish Vastrad Shivaprasad et al.
Journal of neurosciences in rural practice, 7(4), 510-514 (2016-10-04)
Astrocytomas are the most common primary tumor of the central nervous system. The distinction between different tumor grades can be tested despite criteria given by the World Health Organization (WHO). Ki-67 is a potent biological marker used in grading of
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