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Merck
CN

275R-3

Ki-67 (MRQ-64) Rabbit Monoclonal Antibody

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关于此项目

UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
MRQ-64, monoclonal
Application:
IHC (p)
Citations:
9

主要文件

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biological source

rabbit

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

MRQ-64, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (275R-34), vial of 0.1 mL concentrate Research Use Only (275R-34-RUO), vial of 0.5 mL concentrate (275R-35), vial of 1.0 mL concentrate (275R-36), vial of 1.0 mL concentrate Research Use Only (275R-36-RUO), vial of 1.0 mL pre-dilute Research Use Only (275R-37-RUO), vial of 1.0 mL pre-dilute ready-to-use (275R-37), vial of 25.0 mL pre-dilute ready-to-use (275R-30), vial of 25.0 mL pre-dilute ready-to-use Research Use Only (275R-30-RUO), vial of 7.0 mL pre-dilute ready-to-use (275R-38), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (275R-38-RUO)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotype

IgG

control

Burkitt lymphoma, breast (ductl carcinoma in situ), tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Quality Level

100, 500

Gene Information

human ... MKI67(4288)

相关类别

General description

Ki-67 (MRQ-64) is an antibody designed to target Ki-67 antigen-a nuclear protein encoded by the MKI67 gene whose presence correlates with G1, S, G2, and the mitotic phases of the cell cycle.1 Though its specific role is largely postulated and still yet to be determined, Ki-67′s presence during cellular division makes it an excellent target for labeling rapidly growing malignancies.2 Given that its presence correlates with cell proliferation, the immunohistochemical labeling of Ki-67 antigen may be useful in characterizing a lesion′s growth fraction. It has been demonstrated that identifying this antigen by IHC is useful in characterizing lesions of the breast, lymphoid cells, astrocytes, and uterus.3-9

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Ki-67 Positive Control Slides, Product No. 275S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

监管及禁止进口产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000528384
0000499578
0000499578
0000515311
0000515311

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Adi Broyde et al.
American journal of hematology, 84(6), 338-343 (2009-04-23)
Expression of Ki-67, a nuclear antigen protein present in all cycling cells, is used to determine the growth fraction of tumors. The aim of this study was to evaluate the role and prognostic significance of the Ki-67 proliferation index (PI)
Xiaoming Sun et al.
Chromosoma, 127(2), 175-186 (2018-01-13)
Ki-67 protein has been widely used as a proliferation marker for human tumor cells for decades. In recent studies, multiple molecular functions of this large protein have become better understood. Ki-67 has roles in both interphase and mitotic cells, and
Nandish Vastrad Shivaprasad et al.
Journal of neurosciences in rural practice, 7(4), 510-514 (2016-10-04)
Astrocytomas are the most common primary tumor of the central nervous system. The distinction between different tumor grades can be tested despite criteria given by the World Health Organization (WHO). Ki-67 is a potent biological marker used in grading of
Klaus Mayerhofer et al.
Acta obstetricia et gynecologica Scandinavica, 83(11), 1085-1088 (2004-10-19)
The aim of the current study was to evaluate the expression of Ki-67 in uterine smooth muscle tumors, comparing leiomyomas, uterine smooth muscle tumors of uncertain malignant potential (STUMP) and uterine leiomyosarcomas (LMS) and to prove the accuracy of a
T Scholzen et al.
Journal of cellular physiology, 182(3), 311-322 (2000-02-01)
The expression of the human Ki-67 protein is strictly associated with cell proliferation. During interphase, the antigen can be exclusively detected within the nucleus, whereas in mitosis most of the protein is relocated to the surface of the chromosomes. The
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