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27883

香豆雌酚

Name: 香豆雌酚
Brand: SIGMA

BioReagent, suitable for fluorescence, ≥97.5% (HPLC)

别名:

7,12-苯二羟基香豆素

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关于此项目

经验公式（希尔记法）:

C₁₅H₈O₅

化学文摘社编号:

479-13-0

分子量:

268.22

UNSPSC Code:

41116107

NACRES:

NA.77

PubChem Substance ID:

57648278

EC Number:

207-525-6

Beilstein/REAXYS Number:

266702

MDL number:

MFCD00016885

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属性

product line

BioReagent

Quality Level

100

assay

≥97.5% (HPLC)

form

powder

mp

≥350 °C (lit.)

solubility

DMSO: soluble

fluorescence

λ_ex 377 nm; λ_em 437 nm in 0.1 M Tris pH 8.0

suitability

suitable for fluorescence

SMILES string

Oc1ccc-2c(OC(=O)c3c-2oc4cc(O)ccc34)c1

InChI

1S/C15H8O5/c16-7-1-3-9-11(5-7)19-14-10-4-2-8(17)6-12(10)20-15(18)13(9)14/h1-6,16-17H

InChI key

ZZIALNLLNHEQPJ-UHFFFAOYSA-N

Gene Information

human ... ESR1(2099), ESR2(2100)
mouse ... Esr1(13982)
rat ... Ar(24208)

说明

Biochem/physiol Actions

香豆酚通过雌激素受体-α的介导而对大脑和垂体具有抗雌激素作用。

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pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Effect of soybean coumestrol on Bradyrhizobium japonicum nodulation ability, biofilm formation, and transcriptional profile.

Hae-In Lee et al.

Applied and environmental microbiology, 78(8), 2896-2903 (2012-02-07)

Flavonoids, secondary plant metabolites which mainly have a polyphenolic structure, play an important role in plant-microbe communications for nitrogen-fixing symbiosis. Among 10 polyphenolic compounds isolated from soybean roots in our previous study, coumestrol showed the highest antioxidant activity. In this

Phytoestrogen and fiber intakes in relation to incident vasomotor symptoms: results from the Study of Women's Health Across the Nation.

Ellen B Gold et al.

Menopause (New York, N.Y.), 20(3), 305-314 (2013-02-26)

Although reduction of vasomotor symptoms (VMS; hot flashes and night sweats) has been reported in postmenopausal women who used isoflavones, a clear dose response has not been shown, has largely not been reported for perimenopausal women, and has largely only

Phytoestrogens directly inhibit TNF-α-induced bone resorption in RAW264.7 cells by suppressing c-fos-induced NFATc1 expression.

Sahar Karieb et al.

Journal of cellular biochemistry, 112(2), 476-487 (2011-01-27)

TNF-α-induced osteoclastogenesis is central to post-menopausal and inflammatory bone loss, however, the effect of phytoestrogens on TNF-α-induced bone resorption has not been studied. The phytoestrogens genistein, daidzein, and coumestrol directly suppressed TNF-α-induced osteoclastogenesis and bone resorption. TRAP positive osteoclast formation

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全球贸易项目编号

货号	GTIN
27883-5MG	04061833279120
27883-1MG	04061826205051