27883
香豆雌酚
BioReagent, suitable for fluorescence, ≥97.5% (HPLC)
别名:
7,12-苯二羟基香豆素
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关于此项目
经验公式(希尔记法):
C15H8O5
化学文摘社编号:
分子量:
268.22
Beilstein:
266702
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.77
产品线
BioReagent
质量水平
方案
≥97.5% (HPLC)
表单
powder
mp
≥350 °C (lit.)
溶解性
DMSO: soluble
荧光
λex 377 nm; λem 437 nm in 0.1 M Tris pH 8.0
适用性
suitable for fluorescence
SMILES字符串
Oc1ccc-2c(OC(=O)c3c-2oc4cc(O)ccc34)c1
InChI
1S/C15H8O5/c16-7-1-3-9-11(5-7)19-14-10-4-2-8(17)6-12(10)20-15(18)13(9)14/h1-6,16-17H
InChI key
ZZIALNLLNHEQPJ-UHFFFAOYSA-N
基因信息
human ... ESR1(2099), ESR2(2100)
mouse ... Esr1(13982)
rat ... Ar(24208)
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生化/生理作用
香豆酚通过雌激素受体-α的介导而对大脑和垂体具有抗雌激素作用。
警示用语:
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Man-Hai Liu et al.
Neurological research, 33(6), 663-672 (2011-06-29)
Estrogen replacement therapy can decrease the risk of developing Alzheimer's disease. Phytoestrogens have been proposed as potential alternatives to estrogen replacement therapy. The purpose of this study was to evaluate the in vitro protective effects of coumestrol on mice astrocytes.
Sarah J Lowry et al.
Nutrition and cancer, 64(6), 783-789 (2012-08-07)
Some forms of estrogen are associated with breast cancer risk as well as with mammographic density (MD), a strong marker of breast cancer risk. Whether phytoestrogen intake affects breast density, however, remains unclear. We evaluated the association between serum levels
Corinne C Hoerger et al.
Journal of agricultural and food chemistry, 59(3), 847-856 (2011-01-06)
We developed and validated three different sample preparation and extraction methods followed by HPLC-MS/MS (negative electrospray ionization) analysis for the quantification of estrogenic isoflavones (formononetin, daidzein, equol, biochanin A, and genistein) and coumestrol in red clover, soil, and manure. Plant
Elisa V Bandera et al.
BMC women's health, 11, 40-40 (2011-09-29)
While there is extensive literature evaluating the impact of phytoestrogen consumption on breast cancer risk, its role on ovarian cancer has received little attention. We conducted a population-based case-control study to evaluate phytoestrogen intake from foods and supplements and epithelial
Suzan L Carmichael et al.
Nutrition journal, 10, 105-105 (2011-10-08)
Phytoestrogens may be associated with a variety of different health outcomes, including outcomes related to reproductive health. Recently published data on phytoestrogen content of a wide range of foods provide an opportunity to improve estimation of dietary phytoestrogen intake. Using
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