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27883

Sigma-Aldrich

香豆雌酚

BioReagent, suitable for fluorescence, ≥97.5% (HPLC)

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别名:
7,12-苯二羟基香豆素
经验公式（希尔记法）:
C15H8O5
CAS号:
479-13-0
分子量:
268.22
Beilstein:
266702
EC 号:
207-525-6
MDL编号:
MFCD00016885
PubChem化学物质编号:
57648278
NACRES:
NA.77

产品线

BioReagent

质量水平

100

检测方案

≥97.5% (HPLC)

形式

powder

mp

≥350 °C (lit.)

溶解性

DMSO: soluble

荧光

λex 377 nm; λem 437 nm in 0.1 M Tris pH 8.0

适用性

suitable for fluorescence

SMILES字符串

Oc1ccc-2c(OC(=O)c3c-2oc4cc(O)ccc34)c1

InChI

1S/C15H8O5/c16-7-1-3-9-11(5-7)19-14-10-4-2-8(17)6-12(10)20-15(18)13(9)14/h1-6,16-17H

InChI key

ZZIALNLLNHEQPJ-UHFFFAOYSA-N

基因信息

human ... ESR1(2099) , ESR2(2100)
mouse ... Esr1(13982)
rat ... Ar(24208)

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生化/生理作用

香豆酚通过雌激素受体-α的介导而对大脑和垂体具有抗雌激素作用。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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Elisa V Bandera et al.
BMC women's health, 11, 40-40 (2011-09-29)
While there is extensive literature evaluating the impact of phytoestrogen consumption on breast cancer risk, its role on ovarian cancer has received little attention. We conducted a population-based case-control study to evaluate phytoestrogen intake from foods and supplements and epithelial
Corinne C Hoerger et al.
Journal of agricultural and food chemistry, 59(3), 847-856 (2011-01-06)
We developed and validated three different sample preparation and extraction methods followed by HPLC-MS/MS (negative electrospray ionization) analysis for the quantification of estrogenic isoflavones (formononetin, daidzein, equol, biochanin A, and genistein) and coumestrol in red clover, soil, and manure. Plant
Sarah J Lowry et al.
Nutrition and cancer, 64(6), 783-789 (2012-08-07)
Some forms of estrogen are associated with breast cancer risk as well as with mammographic density (MD), a strong marker of breast cancer risk. Whether phytoestrogen intake affects breast density, however, remains unclear. We evaluated the association between serum levels
Ellen B Gold et al.
Menopause (New York, N.Y.), 20(3), 305-314 (2013-02-26)
Although reduction of vasomotor symptoms (VMS; hot flashes and night sweats) has been reported in postmenopausal women who used isoflavones, a clear dose response has not been shown, has largely not been reported for perimenopausal women, and has largely only
Gail A Greendale et al.
Menopause (New York, N.Y.), 19(8), 894-903 (2012-03-15)
Phytoestrogens, which consist mainly of isoflavones, lignans, and coumestans have estrogenic and anti-inflammatory properties. Previous research suggests that higher dietary or supplemental intakes of isoflavones and lignans are related to better cognitive performance in middle-aged and older women. We conducted
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