27883
香豆雌酚
BioReagent, suitable for fluorescence, ≥97.5% (HPLC)
别名:
7,12-苯二羟基香豆素
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经验公式（希尔记法）:
C15H8O5
化学文摘社编号:
分子量:
268.22
UNSPSC Code:
41116107
NACRES:
NA.77
PubChem Substance ID:
EC Number:
207-525-6
Beilstein/REAXYS Number:
266702
MDL number:
InChI key
ZZIALNLLNHEQPJ-UHFFFAOYSA-N
InChI
1S/C15H8O5/c16-7-1-3-9-11(5-7)19-14-10-4-2-8(17)6-12(10)20-15(18)13(9)14/h1-6,16-17H
SMILES string
Oc1ccc-2c(OC(=O)c3c-2oc4cc(O)ccc34)c1
product line
BioReagent
assay
≥97.5% (HPLC)
form
powder
mp
≥350 °C (lit.)
solubility
DMSO: soluble
fluorescence
λex 377 nm; λem 437 nm in 0.1 M Tris pH 8.0
suitability
suitable for fluorescence
Quality Level
Gene Information
human ... ESR1(2099), ESR2(2100)
mouse ... Esr1(13982)
rat ... Ar(24208)
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Biochem/physiol Actions
香豆酚通过雌激素受体-α的介导而对大脑和垂体具有抗雌激素作用。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Yun-hyeok Choi et al.
Archives of pharmacal research, 33(10), 1651-1654 (2010-11-06)
Bioassay-guided fractionation of the EtOAc-soluble extract of Pueraria lobata based on the inhibition of Aβ-induced toxicity in PC12 cells resulted in the isolation of four known active compounds, genistein (8), biochanin A (9), sissotrin (10), and puerol B (11). Of
Sahar Karieb et al.
Journal of cellular biochemistry, 112(2), 476-487 (2011-01-27)
TNF-α-induced osteoclastogenesis is central to post-menopausal and inflammatory bone loss, however, the effect of phytoestrogens on TNF-α-induced bone resorption has not been studied. The phytoestrogens genistein, daidzein, and coumestrol directly suppressed TNF-α-induced osteoclastogenesis and bone resorption. TRAP positive osteoclast formation
D F Argenta et al.
Die Pharmazie, 66(12), 929-932 (2012-02-09)
A simple, rapid, and sensitive LC method to determine coumestrol incorporated in the lipid nanoemulsions was validated. The analyses were performed at room temperature on a reversed-phase C18 column using a mobile phase composed of methanol/water with 0.1% trifluoracetic acid
Suzan L Carmichael et al.
Nutrition journal, 10, 105-105 (2011-10-08)
Phytoestrogens may be associated with a variety of different health outcomes, including outcomes related to reproductive health. Recently published data on phytoestrogen content of a wide range of foods provide an opportunity to improve estimation of dietary phytoestrogen intake. Using
Gail A Greendale et al.
Menopause (New York, N.Y.), 19(8), 894-903 (2012-03-15)
Phytoestrogens, which consist mainly of isoflavones, lignans, and coumestans have estrogenic and anti-inflammatory properties. Previous research suggests that higher dietary or supplemental intakes of isoflavones and lignans are related to better cognitive performance in middle-aged and older women. We conducted
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