27885
香豆雌酚
≥95.0% (HPLC)
别名:
7,12-苯二羟基香豆素
质量水平
方案
≥95.0% (HPLC)
表单
powder
杂质
≤10.0% water
mp
≥350 °C (lit.)
SMILES字符串
Oc1ccc-2c(OC(=O)c3c-2oc4cc(O)ccc34)c1
InChI
1S/C15H8O5/c16-7-1-3-9-11(5-7)19-14-10-4-2-8(17)6-12(10)20-15(18)13(9)14/h1-6,16-17H
InChI key
ZZIALNLLNHEQPJ-UHFFFAOYSA-N
基因信息
human ... ESR1(2099), ESR2(2100)
mouse ... Esr1(13982)
rat ... Ar(24208)
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应用
- 鱼饲料生产中的植物雌激素：香豆雌酚（coumestrol）被用于鱼饲料生产中的生物标志物，有助于评估这些饲料中使用的植物原料 （Pavlopoulos et al., 2023）。
- 考迈斯托醇和大豆叶片衰老: 考察了香豆雌酚（coumestrol）在大豆叶片衰老中的作用，特别是它与植物激素的相互作用，表明了其潜在的农艺效益和在作物科学中的应用，它可作为一种植物抗毒素（Mun et al., 2021）
- 大豆的系统防御本研究考察了香豆雌酚启动（priming ）对大豆防御根腐线虫的影响，强调了其作为天然植物防御增强剂的潜力(Adss et al., 2021）。
生化/生理作用
香豆酚通过雌激素受体-α的介导而对大脑和垂体具有抗雌激素作用。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Bickoff, E.M., et al.
Journal of the American Chemical Society, 80, 3969-3969 (1958)
Larry M Mallis et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 796(1), 71-86 (2003-10-14)
In recent years, consumption of herbal supplements as an alternative to pharmaceutical drug therapy has increased. For example, with the health claims labeling which describes the link between soy-protein and a reduced risk of coronary heart disease (CHD), the consumption
Camila Franco et al.
International journal of pharmaceutics, 369(1-2), 5-11 (2008-11-26)
Coumestrol is an estrogenic and antioxidant agent, characterized by its low solubility in aqueous and lipophilic media, once in the aglicone form. In order to improve its solubility in water, coumestrol was associated with beta-cyclodextrin in aqueous media followed by
J Młynarczuk et al.
Environmental toxicology, 28(7), 411-418 (2011-06-10)
Coumestrol is one of a few biologically active substances present in leguminous plants, which are widely used as fodder for ruminants. Depending on the doses, coumestrol acts on the reproductive processes as an estrogen-like factor or antiestrogen to evoke a
Ellen B Gold et al.
Menopause (New York, N.Y.), 20(3), 305-314 (2013-02-26)
Although reduction of vasomotor symptoms (VMS; hot flashes and night sweats) has been reported in postmenopausal women who used isoflavones, a clear dose response has not been shown, has largely not been reported for perimenopausal women, and has largely only
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