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Merck
CN

280C-1

Sigma-Aldrich

Mammaglobin Cocktail (304-1A5 & 31A5)

Mouse & Rabbit Cocktail Antibody

别名:

Mammaglobin Cocktail (304-1A5 & 31A5) Mouse/Rabbit Monoclonal Antibodies

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关于此项目

UNSPSC代码:
12352203
NACRES:
NA.41

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生物来源

mouse
rabbit

质量水平

100
300
500

偶联物

unconjugated

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

304-1A5/31A5, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions (See Chart).

表单

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (280C-14-ASR)
vial of 0.5 mL concentrate (280C-15-ASR)
bottle of 1.0 mL predilute (280C-17-ASR)
vial of 1.0 mL concentrate (280C-16-ASR)
bottle of 7.0 mL predilute (280C-18-ASR)

浓度

0.01-1 μg/mL (predilute)
2-270 μg/mL (concentrate)

技术

immunohistochemistry: 1:100-1:500

同位素/亚型

IgG1
IgG

运输

wet ice

储存温度

2-8°C

基因信息

human ... SCGB2A2(4250)

一般描述

Mammaglobin (10 kD) is a breast-associated glycoprotein distantly related to secretoglobin family that includes human uteroglobin and lipophilin. Mammaglobin mRNA is present in high levels in human breast cancer cell lines, which has been shown to be a sensitive marker of breast cancer. When combined with other breast-restricted markers such as GCDFP-15, an overall sensitivity for breast carcinoma of 84% has been achieved. Anti-Mammaglobin can also be used to determine breast origin in the setting of metastatic carcinoma.

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

制备说明

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分析说明


IVD
IVD
IVD
RUO

其他说明

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Zhiqiang Wang et al.
International journal of clinical and experimental pathology, 2(4), 384-389 (2009-01-23)
Identification of metastasis and occult micrometastases of breast cancer demands sensitive and specific diagnostic markers. In this study, we assessed the utility of a mouse monoclonal antibody to human mammaglobin for one such purpose. Immunohistochemical stains were performed on paraffin-embedded
Jae-Ho Han et al.
Archives of pathology & laboratory medicine, 127(10), 1330-1334 (2003-10-03)
Organ specificity is a desirable property of a tumor marker, especially in metastatic adenocarcinomas of unknown primary origin. Mammaglobin, a mammary-specific member of the uteroglobin family, is known to be overexpressed in human breast cancer. We investigated mammaglobin A expression
Rohit Bhargava et al.
American journal of clinical pathology, 127(1), 103-113 (2006-12-06)
There are limited data that compare the usefulness of mammaglobin with gross cystic disease fluid protein-15 (GCDFP-15) in the identification of breast carcinomas. Whole tissue sections of 29 breast carcinomas with matched lymph node metastases and 63 breast carcinomas on
Eiichi Sasaki et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 20(2), 208-214 (2006-12-29)
Previously, we used the reverse transcription-polymerase chain reaction (RT-PCR) to show that mammaglobin (MGB1) can serve as a differential marker of breast cancer metastasis from primary lung cancer. However, mRNA-based methods are not appropriate for use in clinical practices. In
T P Fleming et al.
Annals of the New York Academy of Sciences, 923, 78-89 (2001-02-24)
The mammaglobin gene encodes a 10-kDa glycoprotein that is distantly related to a family of proteins that includes rat estramustine binding protein (EMBP)/prostatein and human Clara cell 10-kDa protein (CC10)/uteroglobin. Among normal adult tissues, mammaglobin mRNA expression has been detected
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