282200
高良姜黄素
autophagy inducing flavonoid
别名:
3,5,7-三羟基黄酮, 高良姜黄素
质量水平
方案
≥95% (HPLC)
表单
powder
颜色
yellow
mp
214-215 °C (lit.)
SMILES字符串
Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3ccccc3
InChI
1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H
InChI key
VCCRNZQBSJXYJD-UHFFFAOYSA-N
基因信息
human ... ADORA2A(135), ADORA3(140), CYP1A2(1544)
rat ... Adora1(29290), Adora2a(25369)
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一般描述
高良姜精是从姜科家族成员中分离出的一种类黄酮，主要用作草药。
应用
高良姜素已用于:
- 作为试验药物用于测试其在顺铂诱导的肾毒性啮齿动物模型中的改善作用
- 测试其对3T3-L1前脂肪细胞向脂肪细胞分化的影响
- 作为核磁共振波谱和质谱的内标物
生化/生理作用
高良姜精具有抗氧化、抗凋亡、抗炎和抗肥胖特性。此外，它还具有抵抗环境和饮食致癌物的抗遗传毒性。高良姜精通过阻止癌细胞增殖、诱导凋亡和自噬以及抑制转移来抑制癌细胞生长。高良姜精还具有抑制CYP1A1（细胞色素P450，家族成员1A1）活性的能力。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
M Y Heo et al.
Mutation research, 488(2), 135-150 (2001-05-10)
Flavonoids are polyphenolic compounds that are present in plants. They have been shown to possess a variety of biological activities at non-toxic concentrations in organisms. Galangin, a member of the flavonol class of flavonoid, is present in high concentrations in
Ameesha Tomar et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 34, 154-161 (2017-09-14)
Cisplatin is a widely used chemotherapeutic agent but now-a-days its usage is limited in clinical chemotherapy because of its severe nephrotoxic effect on renal tissues. Galangin, a flavonoid obtained from ginger family has been demonstrated to have antioxidant, anti-apoptotic and
The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor
Ciolino HP and Yeh GC
British Journal of Cancer, 79(9), 1340-1340 (1999)
Jung-Jin Lee et al.
Scientific reports, 7(1), 8207-8207 (2017-08-16)
In clinical pathology, stent interposition is used to treat vascular disease but can lead to restenosis. Drug-eluting stents (DES) are most commonly used to suppress restenosis but can also have side effects. Therefore, we investigated the anti-proliferative effect and its
Yohan Seo et al.
PloS one, 12(3), e0174935-e0174935 (2017-04-01)
Anoctamin 1 (ANO1), a calcium-activated chloride channel, is highly amplified in prostate cancer, the most common form of cancer and leading causes of cancer death in men, and downregulation of ANO1 expression or its functional activity is known to inhibit
商品
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。
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