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Merck
CN

28605

Sigma-Aldrich

3-氰基伞形酮

BioReagent, suitable for fluorescence, ≥98.0% (TLC)

别名:

3-Cyano-7-hydroxycoumarin

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关于此项目

经验公式(希尔记法):
C10H5NO3
化学文摘社编号:
分子量:
187.15
Beilstein:
153271
MDL编号:
UNSPSC代码:
12352108
PubChem化学物质编号:
NACRES:
NA.32
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产品线

BioReagent

质量水平

方案

≥98.0% (TLC)

表单

powder

mp

≥250 °C (lit.)

溶解性

DMF: soluble
alcohols: soluble

荧光

λex 408 nm; λem 450 nm in methanol

适用性

suitable for fluorescence

SMILES字符串

Oc1ccc2C=C(C#N)C(=O)Oc2c1

InChI

1S/C10H5NO3/c11-5-7-3-6-1-2-8(12)4-9(6)14-10(7)13/h1-4,12H

InChI key

IJQYTHQDUDCJEQ-UHFFFAOYSA-N

基因信息

human ... MIF(4282)

应用

3-Cyano-7-hydroxycoumarin is closely related to 3-cyano-7-ethoxycoumarin which is used as a fluorometric substrate and inhibitor for cytochrome P-450 enzymes and cytochrome P-450-dependent mixed function oxidases. 3-Cyano-7-hydroxycoumarin may be useful to study the kinetics and substrate specificity of cytochrome P-450s.

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

象形图

Exclamation mark

警示用语:

Warning

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Samuel Koenig et al.
Aquatic toxicology (Amsterdam, Netherlands), 108, 11-17 (2011-11-19)
Variations in cytochrome P450 enzyme (CYPs) distribution and function between animal groups could result in differential metabolism and elimination kinetics for certain contaminants. Although a number of studies have suggested that differences in polychlorobiphenyl (PCB) accumulation profiles between crustacea and
Pui-Ying Lam et al.
Chembiochem : a European journal of chemical biology, 21(13), 1905-1910 (2020-02-01)
Doxorubicin is a highly effective chemotherapy agent used to treat many common malignancies. However, its use is limited by cardiotoxicity, and cumulative doses exponentially increase the risk of heart failure. To identify novel heart failure treatment targets, a zebrafish model
Jay J Agarwal et al.
PloS one, 8(5), e63028-e63028 (2013-05-15)
TRAM-34, a clotrimazole analog characterized as a potent and selective inhibitor of intermediate-conductance, calcium-activated K(+) (IKCa) channels, has been used extensively in vitro and in vivo to study the biological roles of these channels. The major advantage of TRAM-34 over
Joonyoung F Joung et al.
Physical chemistry chemical physics : PCCP, 19(37), 25509-25517 (2017-09-14)
Proton dissociation (PD) reactions of weak acids and proton transfer (PT) processes in aqueous solutions are strongly influenced by ions. However, a detailed molecular picture that describes how ions affect the rates of PD and PT processes is still missing.
Gowtham Sathyanarayanan et al.
Analytical chemistry, 92(21), 14693-14701 (2020-10-27)
The superfamily of hepatic cytochrome P450 (CYP) enzymes is responsible for the intrinsic clearance of the majority of therapeutic drugs in humans. However, the kinetics of drug clearance via CYPs varies significantly among individuals due to both genetic and external

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