30058
脂肪酶底物
≥95% (HPLC)
别名:
1,2-二-O-月桂基-rac-甘油-3-（戊二酸6-甲基异喹啉酯）
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关于此项目
经验公式（希尔记法）:
C45H69NO8
化学文摘社编号:
分子量:
752.03
NACRES:
NA.83
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
InChI key
FYOMYGYHAZESGQ-UHFFFAOYSA-N
SMILES string
CCCCCCCCCCCCOCC(COC(=O)CCCC(=O)Oc1ccc2N=C3C=CC(=O)C(C)=C3Oc2c1)OCCCCCCCCCCCC
InChI
1S/C45H69NO8/c1-4-6-8-10-12-14-16-18-20-22-31-50-34-38(51-32-23-21-19-17-15-13-11-9-7-5-2)35-52-43(48)25-24-26-44(49)53-37-27-28-39-42(33-37)54-45-36(3)41(47)30-29-40(45)46-39/h27-30,33,38H,4-26,31-32,34-35H2,1-3H3
assay
≥95% (HPLC)
form
powder
solubility
ethanol: soluble (10mg/mL)
fluorescence
λex 529 nm; λem 600 nm in 0.1 M Tris pH 8.4
storage temp.
2-8°C
Quality Level
General description
脂肪酶底物 （1,2-二-O-月桂酰 -外消旋-甘油-3-（戊二酸 6-甲基试卤灵酯, DGGR）是脂肪酶的显色底物。它可用于比色法，用于测量脂肪酶活性。该底物在被脂肪酶消化时会产生一种红紫色化合物甲基试卤灵。
Application
脂肪酶底物可用作高通量筛选试验中的底物，用于测量利普司他汀形成而导致的脂肪酶活性。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Current microbiology, 75(5), 580-587 (2017-12-20)
Pancreatic lipase inhibitors, such as tetrahydrolipstatin (orlistat), are used in anti-obesity treatments. Orlistat is the only anti-obesity drug approved by the European Medicines Agency (EMA). The drug is synthesized by saturation of lipstatin, a β-lactone compound, isolated from Streptomyces toxytricini
Sébastien Cadau et al.
International journal of molecular sciences, 23(21) (2022-11-12)
Atopic dermatitis (AD), the most common inflammatory skin disorder, is a multifactorial disease characterized by a genetic predisposition, epidermal barrier disruption, a strong T helper (Th) type 2 immune reaction to environmental antigens and an altered cutaneous microbiome. Microbial dysbiosis
Ievgeniia Ostrov et al.
Food microbiology, 82, 316-324 (2019-04-28)
Biofilm-forming Bacillus species are often involved in contamination of dairy products and therefore present a major microbiological challenge in the field of food quality and safety. In this study, we sequenced and analyzed the genomes of milk- and non-milk-derived Bacillus
Yan Q Chen et al.
Journal of lipid research, 61(8), 1203-1220 (2020-06-04)
Angiopoietin-like protein (ANGPTL)8 has been implicated in metabolic syndrome and reported to regulate adipose FA uptake through unknown mechanisms. Here, we studied how complex formation of ANGPTL8 with ANGPTL3 or ANGPTL4 varies with feeding to regulate LPL. In human serum
Dongming Lan et al.
Biochemical and biophysical research communications, 488(2), 259-265 (2017-04-24)
Lipases play an important role in physiological metabolism and diseases, and also have multiple industrial applications. Rational modification of lipase specificity may increase the commercial utility of this group of enzymes, but is hindered by insufficient mechanistic understanding. Here, we
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